2. Academic Validation
  3. Genomic analysis of DUSP6, a dual specificity MAP kinase phosphatase, in pancreatic cancer

Genomic analysis of DUSP6, a dual specificity MAP kinase phosphatase, in pancreatic cancer

  • Cytogenet Cell Genet. 1998;82(3-4):156-9. doi: 10.1159/000015091.
T Furukawa 1,  T Yatsuoka,  E M Youssef,  T Abe,  T Yokoyama,  S Fukushige,  E Soeda,  M Hoshi,  Y Hayashi,  M Sunamura,  M Kobari,  A Horii
Affiliations

Affiliation

  • 1 Molecular Pathology, Tohoku University School of Medicine, Sendai; (Japan).
PMID: 9858808 DOI: 10.1159/000015091
Abstract

DUSP6 (alias PYST1), one of the dual-specificity tyrosine phosphatases, is localized on 12q21, one of the regions of frequent allelic loss in pancreatic Cancer. This gene is composed of three exons, and two forms of alternatively spliced transcripts are ubiquitously expressed. Although no mutations were observed in 26 pancreatic Cancer cell lines, reduced expressions of the full-length transcripts were observed in some cell lines, which may suggest some role for DUSP6 in pancreatic carcinogenesis.

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