2. Academic Validation
  3. A new antitumor agent: methyl sulfonium perchlorate of echinomycin

A new antitumor agent: methyl sulfonium perchlorate of echinomycin

  • Bioorg Med Chem Lett. 1998 Apr 7;8(7):731-4. doi: 10.1016/s0960-894x(98)00113-9.
Y S Park 1,  Y H Kim,  S K Kim,  S J Choi
Affiliations

Affiliation

  • 1 Department of Chemistry, Korea Advanced Institute of Science and Technology, Taejon, Korea.
PMID: 9871531 DOI: 10.1016/s0960-894x(98)00113-9
Abstract

Newly modified-echinomycin such as S-methylated sulfonium perchlorate of echinomycin (1), monosulfoxide (2), disulfoxid (3) and sulfone (4) have been prepared and evaluated for in vitro biological activities of cytotoxicity against P388, B16 and SNU-16 as well as in vivo antitumor activity against murine leukemia P388 and melanoma B16.

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