2. Academic Validation
  3. Solid phase organic synthesis of polyamine derivatives and initial biological evaluation of their antitumoral activity

Solid phase organic synthesis of polyamine derivatives and initial biological evaluation of their antitumoral activity

  • Bioorg Med Chem Lett. 1998 Mar 17;8(6):635-40. doi: 10.1016/s0960-894x(98)00086-9.
S Tomasi 1,  M Le Roch,  J Renault,  J C Corbel,  P Uriac,  B Carboni,  D Moncoq,  B Martin,  J G Delcros
Affiliations

Affiliation

  • 1 Pharmacochimie de Molécules de Synthèse et de Produits Naturels, Faculté de Pharmacie, Rennes, France.
PMID: 9871574 DOI: 10.1016/s0960-894x(98)00086-9
Abstract

A series of N1-monosubstituted putrescine and spermine derivatives was synthesised using a solid phase methodology. We evaluated their cytotoxicity, Calmodulin antagonism and polyamine uptake inhibition, pharmacological properties shared by some antitumoral agents.

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