2. Academic Validation
  3. A paclitaxel analogue with a 2(3-->20)abeotaxane skeleton: synthesis and biological evaluation

A paclitaxel analogue with a 2(3-->20)abeotaxane skeleton: synthesis and biological evaluation

  • Bioorg Med Chem Lett. 1998 Feb 3;8(3):273-6. doi: 10.1016/s0960-894x(98)00005-5.
J Soto 1,  J L Mascareñas,  L Castedo
Affiliations

Affiliation

  • 1 Departamento de Química Orgánica, Facultade de Química, Universidade de Santiago de Compostela, Spain.
PMID: 9871668 DOI: 10.1016/s0960-894x(98)00005-5
Abstract

A paclitaxel analogue having an unusual tricyclic [9.3.1.1] hexadecane skeleton was synthesized from deaminoacyltaxine A, a 2(3-->20) abeotaxane isolated in considerable amounts from the leaves of Taxus baccata L. In preliminary studies, this compound showed a much lower cytotoxicity than paclitaxel.

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