2. Academic Validation
  3. Synthesis of Dolastatin 15 mimetic peptoids

Synthesis of Dolastatin 15 mimetic peptoids

  • Bioorg Med Chem Lett. 1998 Feb 17;8(4):385-8. doi: 10.1016/s0960-894x(98)00034-1.
J Schmitt 1,  M Bernd,  B Kutscher,  H Kessler
Affiliations

Affiliation

  • 1 Institut für Organische Chemie und Biochemie Technischen Universität München, Garching, Germany.
PMID: 9871690 DOI: 10.1016/s0960-894x(98)00034-1
Abstract

Eight peptoids have been synthesized as peptidomimetics of the cytostatic Dolastatin 15, a depsipeptide isolated from the Indian sea hare Dolabella auricularia. The compounds have been tested against several human Cancer cell lines and did not show any cytostatic properties.

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