2. Academic Validation
  3. Novel D-ring analogues of podophyllotoxin as potent anti-cancer agents

Novel D-ring analogues of podophyllotoxin as potent anti-cancer agents

  • Bioorg Med Chem Lett. 1998 Jun 2;8(11):1391-6. doi: 10.1016/s0960-894x(98)00232-7.
D Subrahmanyam 1,  B Renuka,  C V Rao,  P S Sagar,  D S Deevi,  J M Babu,  K Vyas
Affiliations

Affiliation

  • 1 Natural Products Division, Dr. Reddy's Research Foundation, Miyapur, Hyderabad, India.
PMID: 9871772 DOI: 10.1016/s0960-894x(98)00232-7
Abstract

Several D-ring modified analogues of podophyllotoxin were prepared viz semi-synthesis starting from naturally occurring podophyllotoxin and determined their in vitro anti-cancer activity. Most of the analogues have shown good activity towards human Cancer cell lines.

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