2. Academic Validation
  3. Serine derived NK1 antagonists. 1: The effect of modifications to the serine substituents

Serine derived NK1 antagonists. 1: The effect of modifications to the serine substituents

  • Bioorg Med Chem Lett. 1998 Jul 21;8(14):1845-50. doi: 10.1016/s0960-894x(98)00320-5.
J M Elliott 1,  M A Cascieri,  G Chicchi,  S Davies,  F J Kelleher,  M Kurtz,  T Ladduwahetty,  R T Lewis,  A M MacLeod,  K J Merchant,  S Sadowski,  G I Stevenson
Affiliations

Affiliation

  • 1 Merck Sharp and Dohme Research Laboratories, Neuroscience Research Center, Harlow, Essex, U.K. [email protected]
PMID: 9873445 DOI: 10.1016/s0960-894x(98)00320-5
Abstract

A series of novel serine derived NK1 antagonists is described. The effect of variations in the N-benzyl, O-benzyl and serine groups are used to define the elements which are necessary for binding.

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