2. Academic Validation
  3. New antifungals selected by molecular topology

New antifungals selected by molecular topology

  • Bioorg Med Chem Lett. 1998 Sep 22;8(18):2577-82. doi: 10.1016/s0960-894x(98)00460-0.
L Pastor 1,  R García-Domenech,  J Gálvez,  S Wolski,  M D García
Affiliations

Affiliation

  • 1 Unidad de Investigación de Diseño de Fármacos, Facultad de Farmacia, Universitat de Valencia, Spain.
PMID: 9873584 DOI: 10.1016/s0960-894x(98)00460-0
Abstract

Molecular topology has been applied to find the new lead antimycotic compounds. Among the selected compounds stands out 3,3'-(4,4'-Biphenylene)bis(2,5-diphenyl-2H-tetrazolium chloride), Benztropine mesylate and Dicyclopentamethylenethiuram disulphide, with minimum inhibitory concentrations between 1.6 and 2 micrograms/mL.

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