2. Academic Validation
  3. Novel protein kinase C inhibitors: alpha-terthiophene derivatives

Novel protein kinase C inhibitors: alpha-terthiophene derivatives

  • Bioorg Med Chem Lett. 1998 Oct 6;8(19):2695-8. doi: 10.1016/s0960-894x(98)00468-5.
D S Kim 1,  C L Ashendel,  Q Zhou,  C T Chang,  E S Lee,  C J Chang
Affiliations

Affiliation

  • 1 Department of Medicinal Chemistry, Purdue University, West Lafayette, IN 47907-1333, USA.
PMID: 9873605 DOI: 10.1016/s0960-894x(98)00468-5
Abstract

A series of alpha-terthiophene derivatives were prepared and their protein kinase C inhibitory activity were evaluated. The aldehyde derivatives were most potent inhibitors (IC50 < 1 microM). alpha-Terthiophene monoaldehyde was inactive in the inhibitions of protein kinase A, mitogen activated protein kinase and protein tyrosine kinase.

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