Poly(styrenyl acetal trehalose)  (Synonyms: pSAT)

Poly(styrenyl acetal trehalose) (pSAT) is composed of trehalose side chains linked to a polystyrene backbone via acetals. Poly(styrenyl acetal trehalose) stabilizes a variety of proteins and enzymes against fluctuations in temperature, and does not trigger the innate immune response. Poly(styrenyl acetal trehalose) can be used in synthesis of protein-polymer conjugates for reduced renal clearance of the biomolecule^[1].

Poly(styrenyl acetal trehalose) (10 mg/kg; IV, single dosage) does not induce liver or kidney damage, and is safe in terms of acute toxicity in mice^[1].
Poly(styrenyl acetal trehalose) (1 mg/kg; IP, twice, at the 0 and 14 day) does not induce the increase of pro-inflammatory cytokines and IgG^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

C₂₃H₃₄O₁₁

O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@H]2O[C@H]3[C@@H](OC(C4=CC=C(C(CC)C)C=C4)OC3)[C@H](O)[C@H]2O.[n]

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Ko JH, et al. Safety and Biodistribution Profile of Poly(styrenyl acetal trehalose) and Its Granulocyte Colony Stimulating Factor Conjugate. Biomacromolecules. 2022 Jun 29.  [Content Brief]