1. Recombinant Proteins
  2. Immune Checkpoint Proteins
  3. Stimulatory immune checkpoint molecules
  4. CD40 & CD40L

CD40, also known as Bp50 and TNFRSF5, is a type I transmembrane protein which belongs to the TNF receptor (TNFR) superfamily. It is expressed on APC such as dendritic cells (DC), B cells, and monocytes as well as many non-immune cells and a wide range of tumors. CD40 ligand, CD40L (also known as gp39, CD154 and TNFSF5) is a type II membrane glycoprotein which is a member of TNF superfamily (TNFSF). CD40L is expressed preferentially by activated CD4+ T cells and activated platelets, although it can also be variably expressed by monocytic cells, natural killer cells, B cells, CD8+ T cells, mast cells, and basophils. CD40-CD40L is a pair of co-stimulatory molecules and plays a broad role in various immunological processes contributing to both humoral and cell-mediated immune responses. For instance, CD40/CD40L interaction stimulates cytokines secretion of B cells with subsequent T cell activation and tumor cell death.

Cat. No. Product Name / Synonyms Species Source
Cat. No. Product Name Effect Purity