DRI-C21041 (DIEA) 

DRI-C21041 DIEA is a CD40/CD40L interaction inhibitor, with an IC₅₀ of 0.31 μM. DRI-C21041 DIEA inhibits the immune response induced by alloantigen^[1].

DRI-C21041 DIEA inhibits CD40L-induced B-cell activation, proliferation, and the activation of NF-κB^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

696.81

C₃₈H₄₀N₄O₇S

Solid

Light yellow to yellow

O=S(C1=C2C(NC(C3=CC=C(C4=CC=C(NC(C5=CC=C([N+]([O-])=O)C=C5)=O)C=C4)C=C3)=O)=CC=CC2=CC=C1)(O)=O.CCN(C(C)C)C(C)C

Room temperature in continental US; may vary elsewhere.

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

• [1]. Lu H, et, al. Recent advances in the development of protein-protein interactions modulators: mechanisms and clinical trials. Signal Transduct Target Ther. 2020 Sep 23;5(1):213.  [Content Brief]