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DRI-C21045 

Cat. No.: HY-120323
Handling Instructions

DRI-C21045 (compound 10) is a potent and selective inhibitor of the CD40-CD40L costimulatory protein-protein interaction (PPI) with an IC50 of 0.17 µM. DRI-C21045 shows concentration-dependent inhibition of the activation of NF-κB and B cell proliferation all induced by CD40L with IC50s of 17.1 µM and 4.5 µM, respectively.

For research use only. We do not sell to patients.

DRI-C21045 Chemical Structure

DRI-C21045 Chemical Structure

CAS No. : 2101765-81-3

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Description

DRI-C21045 (compound 10) is a potent and selective inhibitor of the CD40-CD40L costimulatory protein-protein interaction (PPI) with an IC50 of 0.17 µM. DRI-C21045 shows concentration-dependent inhibition of the activation of NF-κB and B cell proliferation all induced by CD40L with IC50s of 17.1 µM and 4.5 µM, respectively[1].

IC50 & Target

IC50: 0.17 µM (CD40)[1]

Molecular Weight

578.63

Formula

C₃₃H₂₆N₂O₆S

CAS No.

2101765-81-3

SMILES

O=S(C1=CC=CC2=CC=CC(NC(C3=CC=C(C4=CC=C(NC(C5=CC=C(C(OC)=O)C=C5)=O)C=C4)C=C3)=O)=C21)(C)=O

Shipping

Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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DRI-C21045
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