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  2. TNF Receptor
  3. DRI-C21045

DRI-C21045 

Cat. No.: HY-120323 Purity: 98.26%
Handling Instructions

DRI-C21045 (compound 10) is a potent and selective inhibitor of the CD40-CD40L costimulatory protein-protein interaction (PPI) with an IC50 of 0.17 µM. DRI-C21045 shows concentration-dependent inhibition of the activation of NF-κB and B cell proliferation all induced by CD40L with IC50s of 17.1 µM and 4.5 µM, respectively.

For research use only. We do not sell to patients.

DRI-C21045 Chemical Structure

DRI-C21045 Chemical Structure

CAS No. : 2101765-81-3

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Free Sample (0.5-1 mg)   Apply Now  
10 mg USD 200 In-stock
Estimated Time of Arrival: December 31
50 mg USD 600 In-stock
Estimated Time of Arrival: December 31
100 mg USD 980 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

DRI-C21045 (compound 10) is a potent and selective inhibitor of the CD40-CD40L costimulatory protein-protein interaction (PPI) with an IC50 of 0.17 µM. DRI-C21045 shows concentration-dependent inhibition of the activation of NF-κB and B cell proliferation all induced by CD40L with IC50s of 17.1 µM and 4.5 µM, respectively[1].

IC50 & Target

IC50: 0.17 µM (CD40)[1]

Molecular Weight

580.61

Formula

C₃₂H₂₄N₂O₇S

CAS No.
SMILES

O=S(C1=CC=CC2=CC=CC(NC(C3=CC=C(C4=CC=C(NC(C5=CC=C(C(OC)=O)C=C5)=O)C=C4)C=C3)=O)=C21)(O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 2 mg/mL (3.44 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7223 mL 8.6116 mL 17.2233 mL
5 mM --- --- ---
10 mM --- --- ---
*Please refer to the solubility information to select the appropriate solvent.
References
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Keywords:

DRI-C21045TNF ReceptorTumor Necrosis Factor ReceptorTNFRInhibitorinhibitorinhibit

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Product Name:
DRI-C21045
Cat. No.:
HY-120323
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