CEACAM1

Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1), also known as CD66a, BGP, or C-CAM, is an extensively studied, multifunctional transmembrane protein which is the primordial member of the carcinoembryonic antigen cell adhesion molecule (CEACAM) family of glycosylated immunoglobulin (Ig) molecules. CEACAM1 is expressed by certain epithelial, endothelial, lymphoid and myeloid cells. The full-length protein consists of an amino-terminal, membrane-distal IgV-like domain, followed by up to three membrane-proximal IgC2-like domains. In human, CEACAM1 occurs as 12 different alternatively spliced isoforms. CEACAM1 has been demonstrated to play a role in morphogenesis, apoptosis, angiogenesis, cell proliferation, cell motility, fibrosis, and in immune T cell tolerance. In addition, CEACAM1 plays a multi-faceted role as an immune checkpoint inhibitor and tumor marker and thus shows promise in a preclinical setting as a target for cancer immunotherapy.