1. Recombinant Proteins
  2. Fc Receptors
  3. FcμR

FcμR is a high-affinity receptor for the Fc portion of human IgM. It expresses in B cell activation, cell survival and proliferation, but the full range of its functions remains to be elucidated. FcμR binds with similar affinity to pentameric IgM, IgM-Fc homodimer and IgM-Fc lacking the Cμ2 domains. FcμR is a 390-amino acid (aa) polypeptide consisting of a 17-aa signal peptide and 107-aa Ig-like domain, followed by a further 127-aa extracellular region, a 21-aa transmembrane portion that has a charged histidine residue and a 118-aa cytoplasmic tail. The receptor has no N-linked glycosylation site, however, O-linked glycosylation in the stalk region has been reported.

Cat. No. Product Name Effect Purity