1. Recombinant Proteins
  2. Cytokines and Growth Factors
  3. EGF Superfamily
  4. HB-EGF

Heparin-binding epidermal growth factor-like growth factor (HB-EGF) is a heparin-binding member of the EGF family. It is a potent mitogen and chemotactic factor for fibroblasts and smooth muscle cells. HB-EGF is synthesized as a membrane-anchored form (pro-HB-EGF) that is processed by the ADAM family of metalloproteinases to release soluble mature peptide, which as known as “ectodomain shedding”. It is biologically active either as a pro-HB-EGF or as a soluble form (s-HB-EGF). EGF is expressed in a wide range of cell types, including monocytes/macrophages, CD4+ lymphocytes, neutrophils, eosinophils, myeloid leukemia blasts, myeloma cells, vascular smooth muscle cells, endothelial and normal, or neoplastic epithelial cells. The pro-HB-EGF as a cell-to-cell adhesion protein that exerts mainly inhibitory juxtacrine activities involved in cell cycle arrest and growth inhibition as well as resistance to apoptosis. As a native ligand of EGFR and ErbB4, HB-EGF exerts its activities by binding to its receptors. It is involved in a number of physiological and pathological processes, which include wound healing, cardiac hypertrophy, smooth muscle cell hyperplasia, kidney collecting duct morphogenesis, blastocyst implantation, pulmonary hypertension, and oncogenic transformation.

Cat. No. Product Name Effect Purity