1. Recombinant Proteins
  2. Cytokines and Growth Factors
  3. EGF superfamily
  4. HB-EGF

Heparin-binding epidermal growth factor-like growth factor (HB-EGF) is a heparin-binding member of the EGF family. It is a potent mitogen and chemotactic factor for fibroblasts and smooth muscle cells. HB-EGF is synthesized as a membrane-anchored form (pro-HB-EGF) that is processed by the ADAM family of metalloproteinases to release soluble mature peptide, which as known as “ectodomain shedding”. It is biologically active either as a pro-HB-EGF or as a soluble form (s-HB-EGF). EGF is expressed in a wide range of cell types, including monocytes/macrophages, CD4+ lymphocytes, neutrophils, eosinophils, myeloid leukemia blasts, myeloma cells, vascular smooth muscle cells, endothelial and normal, or neoplastic epithelial cells. The pro-HB-EGF as a cell-to-cell adhesion protein that exerts mainly inhibitory juxtacrine activities involved in cell cycle arrest and growth inhibition as well as resistance to apoptosis. As a native ligand of EGFR and ErbB4, HB-EGF exerts its activities by binding to its receptors. It is involved in a number of physiological and pathological processes, which include wound healing, cardiac hypertrophy, smooth muscle cell hyperplasia, kidney collecting duct morphogenesis, blastocyst implantation, pulmonary hypertension, and oncogenic transformation.

Cat. No. Product Name / Synonyms Species Source
  • HY-P7017
    HB-EGF Protein, Human

    rHuHB-EGF; HBEGF; Diphtheria toxin receptor; DTR

    Human E. coli
    HB-EGF Protein, Human is a member of the epidermal growth factor (EGF) family of growth factors that stimulate growth and differentiation.
  • HY-P7194
    HB-EGF Protein, Mouse

    rMuHB-EGF; Proheparin-binding EGF-like growth factor; HBEGF; DTR

    Mouse E. coli
    HB-EGF Protein, Mouse is shown to play a role in wound healing, cardiac hypertrophy, and heart development and function.
  • HY-P7400
    HB-EGF Protein, Human (CHO)

    rHuProheparin-binding EGF-like Growth Factor; DTR; DTS; HEGFL

    Human CHO
    HB-EGF Protein, Human (CHO) is shown to play a role in wound healing, cardiac hypertrophy, and heart development and function.
  • HY-P72487
    HB-EGF Protein, Human (HEK 293, His)

    Proheparin-binding EGF-like growth factor; HB-EGF; DT-R; DTS; HEGFL

    Human HEK293
  • HY-P73093
    HB-EGF Protein, Human (sf9)

    Proheparin-binding EGF-like Growth Factor; DTR; DTS; HEGFL; HBEGF

    Human Sf9 insect cells
  • HY-P73295
    MDK Protein, Human (sf9)

    Midkine; MK; ARAP; MDK; MK1; NEGF2

    Human Sf9 insect cells
Cat. No. Product Name Effect Purity