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  5. CD26/Dipeptidyl Peptidase 4 Protein, Mouse (HEK293, His)

CD26/Dipeptidyl Peptidase 4 Protein, Mouse (HEK293, His)

Cat. No.: HY-P75428
COA Handling Instructions

CD26/dipeptidyl peptidase 4 is a key cell surface receptor for T cell activation. It binds to ADA, CAV1, IGF2R and PTPRC to promote T cell proliferation and NF-kappa-B activation. CD26/Dipeptidyl Peptidase 4 Protein, Mouse (HEK293, His) is the recombinant mouse-derived CD26/Dipeptidyl Peptidase 4 protein, expressed by HEK293 , with C-His labeled tag. The total length of CD26/Dipeptidyl Peptidase 4 Protein, Mouse (HEK293, His) is 732 a.a., with molecular weight of ~85.9 kDa.

For research use only. We do not sell to patients.

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Description

CD26/dipeptidyl peptidase 4 is a key cell surface receptor for T cell activation. It binds to ADA, CAV1, IGF2R and PTPRC to promote T cell proliferation and NF-kappa-B activation. CD26/Dipeptidyl Peptidase 4 Protein, Mouse (HEK293, His) is the recombinant mouse-derived CD26/Dipeptidyl Peptidase 4 protein, expressed by HEK293 , with C-His labeled tag. The total length of CD26/Dipeptidyl Peptidase 4 Protein, Mouse (HEK293, His) is 732 a.a., with molecular weight of ~85.9 kDa.

Background

The CD26/Dipeptidyl Peptidase 4 protein serves as a cell surface glycoprotein receptor crucial for the costimulatory signal essential in T-cell receptor (TCR)-mediated T-cell activation. Functioning as a positive regulator of T-cell coactivation, CD26 binds to ADA, CAV1, IGF2R, and PTPRC. Its interactions with CAV1 and CARD11 induce T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Additionally, CD26's association with ADA regulates lymphocyte-epithelial cell adhesion, while its partnership with FAP contributes to pericellular proteolysis of the extracellular matrix (ECM), facilitating the migration and invasion of endothelial cells into the ECM. CD26 may also play a role in promoting lymphatic endothelial cell adhesion, migration, and tube formation. When overexpressed, CD26 enhances cell proliferation, a process inhibited by GPC3. Beyond its coactivation role, CD26 functions as a serine exopeptidase with dipeptidyl peptidase activity, regulating various physiological processes by cleaving peptides in the circulation, including chemokines, mitogenic growth factors, neuropeptides, and peptide hormones, specifically targeting peptides with unsubstituted N-termini when the penultimate residue is proline.

Biological Activity

The enzyme activity of this recombinant protein is testing in progress, we cannot offer a guarantee yet.

Species

Mouse

Source

HEK293

Tag

C-His

Accession

P28843 (S29-H760)

Gene ID
Molecular Construction
N-term
CD26 (S29-H760)
Accession # P28843
His
C-term
Synonyms
Dipeptidyl peptidase 4; ADABP; ADCP-2; DPP IV; TP103; CD26; DPP4
Molecular Weight

Approximately 85.9 kDa

Purity

Greater than 90% as determined by reducing SDS-PAGE.

Appearance

Solution.

Formulation

Supplied as a 0.2 μm filtered solution of PBS, pH 7.4.

Endotoxin Level

<1 EU/μg, determined by LAL method.

Reconstitution

N/A.

Storage & Stability

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping

Shipping with dry ice.

Documentation
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Reconstitution Calculator

  • Dilution Calculator

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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Product Name:
CD26/Dipeptidyl Peptidase 4 Protein, Mouse (HEK293, His)
Cat. No.:
HY-P75428
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