Coagulation factor IX/F9 Protein, Human (461a.a, HEK293, His)

Coagulation factor IX is a vitamin K-dependent plasma protein that participates in the intrinsic pathway of blood coagulation by converting Coagulation factor IX into its active form in the presence of Ca²⁺, phospholipids, and factor VIIIa. Coagulation factor IX/F9 Protein, Human (461a.a, HEK293, His) is the recombinant human-derived Coagulation factor IX/F9 protein, expressed by HEK293 , with C-His labeled tag. The total length of Coagulation factor IX/F9 Protein, Human (461a.a, HEK293, His) is 461 a.a., with molecular weight of 60-80 kDa.

Coagulation factor IX is a vitamin K-dependent protein, and its deficiency can lead to hemophilia B^[1].
Coagulation factor IX is the zymogen of plasma protease factor XIa (fXIa). In the presence of Ca²⁺, phospholipids, and factor VIIIa, coagulation factor IX is proteolytically converted to factor IXaβ (fIXaβ), which promotes the production of thrombin during coagulation. Coagulation factor IX contributes to thrombosis, while playing a relatively minor role in hemostasis^[2][3].

Human

HEK293

C-His

AAB59620.1 (M1-T461)

2158  [NCBI]

60-80 kDa

Greater than 95% as determined by reducing SDS-PAGE

<1 EU/μg, determined by LAL method.