EDA2R/XEDAR Protein, Human (HEK293, Fc)

The EDA2R/XEDAR protein acts as a receptor for the EDA isoform A2 (unlike A1) and is critical for activating the NF-kappa-B and JNK pathways. Its activation involves binding to TRAF3 and TRAF6. EDA2R/XEDAR Protein, Human (HEK293, Fc) is the recombinant human-derived EDA2R/XEDAR protein, expressed by HEK293 , with C-hFc labeled tag. The total length of EDA2R/XEDAR Protein, Human (HEK293, Fc) is 136 a.a., with molecular weight of ~41.3 kDa.

EDA2R/XEDAR Protein serves as a receptor specifically for EDA isoform A2, distinguishing it from isoform A1. This receptor plays a crucial role in mediating the activation of the NF-kappa-B and JNK pathways. The activation process appears to be facilitated through the binding of EDA2R/XEDAR to TRAF3 and TRAF6. Additionally, EDA2R/XEDAR forms associations with TRAF1, TRAF3, and TRAF6, indicating its involvement in intricate signaling networks. These interactions highlight the multifaceted role of EDA2R/XEDAR in cellular signaling pathways, emphasizing its potential impact on immune responses and inflammatory processes.

Human

HEK293

C-hFc

Q9HAV5 (M1-E136)

60401  [NCBI]

Approximately 41.3 kDa

Greater than 95% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.