Integrin beta-1/CD29 Protein, Human (728a.a, HEK293, His)

Integrin beta-1/CD29 forms distinct heterodimers that act as multifunctional receptors for extracellular matrix proteins. It recognizes collagen, fibronectin, fibrinogen and laminin and plays a key role in cell functions such as migration, adhesion and angiogenesis. Integrin beta-1/CD29 Protein, Human (728a.a, HEK293, His) is the recombinant human-derived Integrin beta-1/CD29 protein, expressed by HEK293 , with C-8*His labeled tag. The total length of Integrin beta-1/CD29 Protein, Human (728a.a, HEK293, His) is 708 a.a., with molecular weight of 90-145 kDa.

The Integrin beta-1/CD29 protein, forming heterodimers with various alpha subunits, serves as a versatile receptor for a multitude of extracellular matrix proteins. Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1, and alpha-11/beta-1 recognize collagen, while Integrins alpha-2/beta-2, alpha-3/beta-1, alpha-4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha-11/beta-1, and alpha-V/beta-1 act as receptors for fibronectin. Additionally, Integrin alpha-5/beta-1 serves as a receptor for fibrinogen, and Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-6/beta-1, and alpha-7/beta-1 are receptors for laminin. Specific integrins, such as alpha-4/beta-1 and alpha-9/beta-1, play roles in recognizing VCAM1 and other ligands, contributing to diverse cellular functions including migration, adhesion, and angiogenesis. Beta-1 integrins, recognizing the R-G-D sequence, are implicated in various physiological processes, such as osteoblast compaction, cell motility, and cytokinesis completion. Furthermore, Integrin beta-1/CD29 plays a key role in facilitating cell invasion, matrix degradation, and myoblast differentiation, highlighting its significance in cellular adhesion, signaling, and developmental processes.

Human

HEK293

C-8*His

P05556/CAA30790.1 (Q21-D728)

3688  [NCBI]

QTDENRCLKANAKSCGECIQAGPNCGWCTNSTFLQEGMPTSARCDDLEALKKKGCPPDDIENPRGSKDIKKNKNVTNRSKGTAEKLKPEDIHQIQPQQLVLRLRSGEPQTFTLKFKRAEDYPIDLYYLMDLSYSMKDDLENVKSLGTDLMNEMRRITSDFRIGFGSFVEKTVMPYISTTPAKLRNPCTSEQNCTTPFSYKNVLSLTNKGEVFNELVGKQRISGNLDSPEGGFDAIMQVAVCGSLIGWRNVTRLLVFSTDAGFHFAGDGKLGGIVLPNDGQCHLENNMYTMSHYYDYPSIAHLVQKLSENNIQTIFAVTEEFQPVYKELKNLIPKSAVGTLSANSSNVIQLIIDAYNSLSSEVILENGKLSEGVTISYKSYCKNGVNGTGENGRKCSNISIGDEVQFEISITSNKCPKKDSDSFKIRPLGFTEEVEVILQYICECECQSEGIPESPKCHEGNGTFECGACRCNEGRVGRHCECSTDEVNSEDMDAYCRKENSSEICSNNGECVCGQCVCRKRDNTNEIYSGKFCECDNFNCDRSNGLICGGNGVCKCRVCECNPNYTGSACDCSLDTSTCEASNGQICNGRGICECGVCKCTDPKFQGQTCEMCQTCLGVCAEHKECVQCRAFNKGEKKDTCTQECSYFNITKVESRDKLPQPVQPDPVSHCKEKDVDDCWFYFTYSVNGNNEVMVHVVENPECPTGPD

90-145 kDa

Greater than 95% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.