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lgr4-gpr48-protein-human-cho

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  • HY-P79308
    Lgr5/GPR49 Protein, Human (CHO, hFc)
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    Leucine-rich repeat-containing G-protein coupled receptor 5; lgr5; G-protein coupled receptor 49; G-protein coupled receptor 67; G-protein coupled receptor HG38; gpr49; gpr67; Leucine-rich Repeat Containing G protein-coupled Receptor 5

    		Human CHO
    Lgr5/GPR49 Protein, the receptor for R-spondins, potentiates the canonical Wnt signaling pathway and marks stem cells in the intestinal epithelium and hair follicle. Binding R-spondins (RSPO1-4), Lgr5/GPR49 associates with phosphorylated LRP6 and frizzled receptors, initiating Wnt signaling and amplifying target gene expression. Unlike classical G-protein coupled receptors, Lgr5/GPR49 does not activate heterotrimeric G-proteins, showcasing its unique regulatory role in Wnt signaling. It's crucial for adult intestinal stem cell development and maintenance, identified in a complex with RNF43 and RSPO1, and interacts with RSPO2-4, demonstrating diverse participation in cellular signaling pathways. Lgr5/GPR49 Protein, Human (CHO, hFc) is the recombinant human-derived Lgr5/GPR49 protein, expressed by CHO, with C-hFc labeled tag. The total length of Lgr5/GPR49 Protein, Human (CHO, hFc) is 539 a.a., with molecular weight of 88-110 kDa.

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