1. Recombinant Proteins
  2. Cytokines and Growth Factors
  3. EGF Superfamily
  4. Neuregulins
  5. Neuregulin-2 (NRG2)
  6. Neuregulin-2/NRG2 Protein, Human (HEK293, His)

Neuregulin-2/NRG2 Protein, Human (HEK293, His)

Cat. No.: HY-P74682
COA Handling Instructions

Neuregulin-2/NRG2 protein serves as a direct ligand for the ERBB3 and ERBB4 tyrosine kinase receptors, initiating ligand-stimulated tyrosine phosphorylation and activation of these receptors. At the same time, NRG2 simultaneously recruits ERBB1 and ERBB2 coreceptors, possibly promoting heterodimerization with the EGF receptor. Neuregulin-2/NRG2 Protein, Human (HEK293, His) is the recombinant human-derived Neuregulin-2/NRG2 protein, expressed by HEK293 , with C-His labeled tag. The total length of Neuregulin-2/NRG2 Protein, Human (HEK293, His) is 293 a.a., with molecular weight of ~34 kDa.

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Description

Neuregulin-2/NRG2 protein serves as a direct ligand for the ERBB3 and ERBB4 tyrosine kinase receptors, initiating ligand-stimulated tyrosine phosphorylation and activation of these receptors. At the same time, NRG2 simultaneously recruits ERBB1 and ERBB2 coreceptors, possibly promoting heterodimerization with the EGF receptor. Neuregulin-2/NRG2 Protein, Human (HEK293, His) is the recombinant human-derived Neuregulin-2/NRG2 protein, expressed by HEK293 , with C-His labeled tag. The total length of Neuregulin-2/NRG2 Protein, Human (HEK293, His) is 293 a.a., with molecular weight of ~34 kDa.

Background

Neuregulin-2 (NRG2) functions as a direct ligand for the tyrosine kinase receptors ERBB3 and ERBB4. Upon binding, NRG2 facilitates the recruitment of ERBB1 and ERBB2 coreceptors, leading to ligand-induced tyrosine phosphorylation and activation of the ERBB receptors. Additionally, NRG2 may promote heterodimerization with the EGF receptor. This intricate interaction with ERBB family members suggests a role for NRG2 in modulating diverse cellular processes through the activation of downstream signaling pathways. The binding and activation of ERBB receptors by NRG2 underscore its significance in cellular communication and signal transduction, highlighting its potential involvement in various physiological and developmental contexts.

Species

Human

Source

HEK293

Tag

C-His

Accession

O14511 (C112-K404)

Gene ID

9542  [NCBI]

Molecular Construction
N-term
NRG2 (C112-K404)
Accession # O14511
His
C-term
Synonyms
Pro-neuregulin-2; Pro-NRG2; Neuregulin-2; DON-1; NTAK; NRG-2
Molecular Weight

Approximately 34 kDa

Purity

Greater than 95% as determined by reducing SDS-PAGE.

Appearance

Solution.

Formulation

Supplied as a 0.22 μm filtered solution of PBS, pH 7.4.

Endotoxin Level

<1 EU/μg, determined by LAL method.

Reconstitution

N/A.

Storage & Stability

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping

Shipping with dry ice.

Documentation

Neuregulin-2/NRG2 Protein, Human (HEK293, His) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Reconstitution Calculator

  • Dilution Calculator

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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Product Name:
Neuregulin-2/NRG2 Protein, Human (HEK293, His)
Cat. No.:
HY-P74682
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