OSMR&GP130 Protein, Human (HEK293, His-Flag)

OSMR beta Protein, crucial in immune response, forms the interleukin-23 receptor with IL-23R by associating with IL12RB1. Binding IL23, it activates T-cells, NK cells, and potentially macrophage/myeloid cells through Jak-Stat signaling. Involved in innate and adaptive immunity, IL23 contributes to acute infection response and is implicated in autoimmune diseases and tumorigenesis. In the presence of IL12RB1, OSMR beta forms a heterodimeric IL-23 receptor, interacting with JAK2 and activating STAT3. OSMR&GP130 Protein, Human (HEK293, His-Flag) is a recombinant protein dimer complex containing human-derived OSMR&GP130 protein, expressed by HEK293, with C-His, C-Flag labeled tag. OSMR&GP130 Protein, Human (HEK293, His-Flag), has molecular weight of 100-140 kDa.

The IL-23R protein plays a critical role in immune response by forming the interleukin-23 receptor through its association with IL12RB1. This receptor binds to IL23 and triggers the activation of T-cells, NK cells, and potentially certain macrophage/myeloid cells via the Jak-Stat signaling cascade. IL23 is involved in both innate and adaptive immunity and likely contributes to the acute response to infection in peripheral tissues. Additionally, IL23 is implicated in autoimmune inflammatory diseases and has been shown to be important in tumorigenesis. When IL12RB1 is present, IL-23R forms a heterodimer that acts as the IL-23 receptor and interacts with JAK2 to activate STAT3.

Human

HEK293

C-His;C-Flag

Q99650-1 (E28-M740)&P40189-1 (E23-E619)

9180&3572

100-140 kDa

Greater than 95% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.