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CD200R1 Protein is an Ig superfamily transmembrane glycoprotein expressed on the surface of myeloid cells. CD200R1 Protein can also be induced in certain T-cell subsets. CD200R1 signaling inhibits the expression of proinflammatory molecules. CD200R1 Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived CD200R1 protein, expressed by HEK293 , with C-His labeled tag. The total length of CD200R1 Protein, Cynomolgus (HEK293, His) is 221 a.a., with molecular weight of 43-75 KDa.
TREM-2 protein forms a signaling complex with TYROBP, activates cells upon ligand binding, and acts as a receptor for amyloid beta, lipoproteins, and apolipoproteins. It promotes their uptake by microglia, triggering activation, proliferation, migration, apoptosis and cytokine expression. TREM-2 Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived TREM-2 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of TREM-2 Protein, Cynomolgus (HEK293, His) is 156 a.a., with molecular weight of 28-40 kDa.
CD7 Protein is a 40-kDa membrane protein that belongs to the immunoglobulin superfamily. CD7 is mainly expressed in T cells and natural killer (NK) cells. CD7 plays a vital role in T and NK cell functions after binding to its ligands (K12 protein and galectin-1). CD7 plays an important role in T-cell and T-cell/B-cell interactions during early lymphoid development. CD7 is also invovled in T and NK cell activation and/or adhesion. CD7 Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived CD7 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of CD7 Protein, Cynomolgus (HEK293, His) is 155 a.a., with molecular weight of ~32.0 kDa.
The CD53 Protein, a vital tetraspanin family member, plays an essential role in immune responses, cell adhesion, and signal transduction. Its study enhances understanding of cell membrane organization and function, with potential applications in immunology and cancer research. Classification within the tetraspanin family emphasizes unique contributions to diverse physiological processes. Further exploration promises insights into CD53's role in both normal physiology and pathological conditions. CD53 Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived CD53 protein, expressed by HEK293, with N-His labeled tag. The total length of CD53 Protein, Cynomolgus (HEK293, His) is 75 a.a., with molecular weight of 19-22 kDa.
The CD53 Protein, a vital tetraspanin family member, plays an essential role in immune responses, cell adhesion, and signal transduction. Its study enhances understanding of cell membrane organization and function, with potential applications in immunology and cancer research. Classification within the tetraspanin family emphasizes unique contributions to diverse physiological processes. Further exploration promises insights into CD53's role in both normal physiology and pathological conditions. CD53 Protein, Cynomolgus (HEK293, Fc) is the recombinant cynomolgus-derived CD53 protein, expressed by HEK293, with N-mFc labeled tag. The total length of CD53 Protein, Cynomolgus (HEK293, Fc) is 75 a.a., with molecular weight of ~44 kDa.
CD3 δ protein is a component of the TCR-CD3 complex on T lymphocytes and plays a crucial role in adaptive immunity. Activated by APC, TCR signals through the CD3 chain, including CD3D, CD3E, CD3G, and CD3Z. CD3 delta Protein, Cynomolgus (HEK293, Fc) is the recombinant cynomolgus-derived CD3 delta protein, expressed by HEK293 , with C-hFc labeled tag. The total length of CD3 delta Protein, Cynomolgus (HEK293, Fc) is 84 a.a., with molecular weight of ~35.0 kDa.
CD3γ protein on lymphocytes is a component of the TCR-CD3 complex and is critical for adaptive immune responses. When the TCR is activated, CD3D, CD3E, CD3G, and CD3Z transmit TCR-mediated signals and activate downstream pathways. CD3 gamma Protein, Cynomolgus (P.pastoris, His) is the recombinant cynomolgus-derived CD3 gamma protein, expressed by P. pastoris , with N-His labeled tag. The total length of CD3 gamma Protein, Cynomolgus (P.pastoris, His) is 91 a.a., with molecular weight of ~12.5 kDa.
CD3 δ protein is a component of the TCR-CD3 complex on T lymphocytes and plays a crucial role in adaptive immunity. Activated by APC, TCR signals through the CD3 chain, including CD3D, CD3E, CD3G, and CD3Z. CD3 delta Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived CD3 delta protein, expressed by HEK293 , with C-6*His labeled tag. The total length of CD3 delta Protein, Cynomolgus (HEK293, His) is 84 a.a., with molecular weight of 20-35 kDa.
The CD3E/CD3 epsilon 1-27 peptide is critical in the TCR-CD3 complex, transmitting signals during T cell activation. When APC activates the TCR, CD3E undergoes LCK/FYN-mediated phosphorylation together with ITAM, initiating downstream signaling. CD3 epsilon Protein, Cynomolgus (HEK293, Fc) is the recombinant cynomolgus-derived CD3 epsilon protein, expressed by HEK293 , with C-Fc, C-hFc labeled tag. The total length of CD3 epsilon Protein, Cynomolgus (HEK293, Fc) is 96 a.a., with molecular weight of 38-55 kDa.
The TIM-3/HAVCR2 protein is a cell surface receptor that regulates immune responses by inhibiting macrophage activation and suppressing Th1-mediated autoimmunity. TIM-3/HAVCR2 Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived TIM-3/HAVCR2 protein, expressed by HEK293 , with N-8*His labeled tag. The total length of TIM-3/HAVCR2 Protein, Cynomolgus (HEK293, His) is 180 a.a., with molecular weight of 26-30 kDa.
CRTAM/CD355 Protein is an immunoglobulin-superfamily transmembrane protein, and is a member of nectin-like protein superfamily. CRTAM is also expressed on activated human NK cells, CD8+ T cells and a subset of CD4+ T cells. CRTAM takes part in cellular adhesion, polarity, and proliferation. CRTAM also regulates lymphocyte function, and promotes TCD8+ cell adhesion and retention within the lymph node. Furthermore, CRTAM can interact with Necl-2, and promotes cytotoxicity of NK cells and IFN-γ secretion of CD8+ T cells in vitro, and NK cell-mediated rejection of tumors expressing Necl-2 in vivosup>[3]. CRTAM/CD355 Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived CRTAM/CD355 protein, expressed by HEK293 , with C-6*His labeled tag.
4-1BB (CD137; TNFRSF9), is a surface glycoprotein, a receptor of TNFSF9/4-1BBL, belongs to the tumor necrosis factor (TNF) receptor superfamily. 4-1BB is helpful for T cell activation and development, and also induces peripheral mononuclear cell proliferation and migration to the tumor microenvironment. 4-1BB is also involved in enhancing Nrf2 and NF-κB pathway mediated apoptosis of endothelial cells. CD137/4-1BB Protein, Cynomolgus (HEK293, His) has 163 amino acids (L24-Q186), produced by HEK293 cells with C-terminal 6*His-tag.
CD137/4-1BB Protein lacks conserved residue(s) crucial for feature annotation propagation. CD137/4-1BB Protein, Cynomolgus (HEK293, Fc) is the recombinant cynomolgus-derived CD137/4-1BB protein, expressed by HEK293 , with C-hFc labeled tag. The total length of CD137/4-1BB Protein, Cynomolgus (HEK293, Fc) is 163 a.a., with molecular weight of ~60.0 kDa.
CD40 Protein, a vital TNFR superfamily member, lacks conserved residue(s) crucial for feature annotation propagation, indicating unique structural attributes. This distinctiveness may influence CD40's functional interactions within the TNFR superfamily, underscoring the need for further exploration to unravel its specific roles and regulatory mechanisms in cellular signaling pathways. CD40 Protein, Cynomolgus (HEK293, Fc) is the recombinant cynomolgus-derived CD40 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of CD40 Protein, Cynomolgus (HEK293, Fc) is 173 a.a., with molecular weight of 48-60 kDa.
PD-1 is a cell surface receptor on T and B cells that binds to PD-L1 and PD-L2. PD-1 is an immune checkpoint that protects autoimmunity by promoting apoptosis of antigen-specific T cells in lymph nodes (programmed cell death) and reducing apoptosis of regulatory T cells (anti-inflammatory, inhibitory T cells). The expression of PD-L1 on tumor cells inhibits anti-tumor activity through the binding of PD-1 to effector T cells. PD-1 Protein, Cynomolgus (143a.a, HEK293, Fc) is the recombinant cynomolgus-derived PD-1 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of PD-1 Protein, Cynomolgus (143a.a, HEK293, Fc) is 143 a.a., with molecular weight of 60-75 kDa.
PD-1 is a cell surface receptor on T and B cells that binds to PD-L1 and PD-L2. PD-1 is an immune checkpoint that protects autoimmunity by promoting apoptosis of antigen-specific T cells in lymph nodes (programmed cell death) and reducing apoptosis of regulatory T cells (anti-inflammatory, inhibitory T cells). The expression of PD-L1 on tumor cells inhibits anti-tumor activity through the binding of PD-1 to effector T cells. PD-1 Protein, Cynomolgus (147a.a, HEK293, His) is the recombinant cynomolgus-derived PD-1 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of PD-1 Protein, Cynomolgus (147a.a, HEK293, His) is 147 a.a., with molecular weight of 30-50 kDa.
CD2 Protein mediates T-cell adhesion to other cell types by interacting with CD58 (LFA-3) and CD48/BCM1. Implicated in T-cell triggering, its cytoplasmic domain has signaling functions. CD2 also interacts with CD2AP and PSTPIP1. Moreover, its interaction with FCGR3A modulates NK cell activation and cytotoxicity. CD2 Protein, Cynomolgus (HEK293, hFc) is the recombinant cynomolgus-derived CD2 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of CD2 Protein, Cynomolgus (HEK293, hFc) is 185 a.a., with molecular weight of ~63 kDa.
The NKG2C/CD159c protein is an immune-activating receptor that plays a critical role in self-non-self discrimination. It cooperates with KLRD1 to recognize non-classical MHC class Ib HLA-E loaded with HLA-G peptides, affecting adaptive NK cell function and maternal-fetal tolerance. NKG2C/CD159c Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived NKG2C/CD159c protein, expressed by HEK293 , with N-His labeled tag. The total length of NKG2C/CD159c Protein, Cynomolgus (HEK293, His) is 138 a.a., with molecular weight of 25-30 kDa.
The CD83 protein is involved in antigen presentation or mediating cell interactions following lymphocyte activation. The specific mechanisms by which CD83 affects these processes in the immune response have not been fully elucidated. CD83 Protein, Cynomolgus (HEK293, Fc) is the recombinant cynomolgus-derived CD83 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of CD83 Protein, Cynomolgus (HEK293, Fc) is 143 a.a., with molecular weight of 45-55 & 34 KDa, respectively.
The CD83 protein is involved in antigen presentation or mediating cell interactions following lymphocyte activation. The specific mechanisms by which CD83 affects these processes in the immune response have not been fully elucidated. CD83 Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived CD83 protein, expressed by HEK293 , with C-His labeled tag. The total length of CD83 Protein, Cynomolgus (HEK293, His) is 143 a.a., with molecular weight of ~19 & 21 & 27 KDa, respectively.
TIGIT is a receptor of the Ig superfamily that plays a key role in restricting adaptive and innate immunity. TIGIT can be used as an immune modulator to inhibit the activity of T cells and NK cells, and also regulates the recognition of cancer cells. TIGIT consists of an extracellular immunoglobulin (Ig) variable domain, a type 1 transmembrane domain, and a cytoplasmic tail with two inhibitory motifs. TIGIT Protein, Cynomolgus (HEK293, Fc) is the recombinant cynomolgus-derived TIGIT protein, expressed by HEK293 , with C-hFc labeled tag.
The CEACAM6 protein is a cell surface glycoprotein that promotes calcium- and fibronectin-independent cell-cell adhesion and mediates homo- and heterosexual interactions with other carcinoembryonic antigen-related cell adhesion molecules. CEACAM6 Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived CEACAM6 protein, expressed by HEK293 , with C-His labeled tag. The total length of CEACAM6 Protein, Cynomolgus (HEK293, His) is 323 a.a., with molecular weight of ~33.3 KDa.
CD2 Protein mediates T-cell adhesion to other cell types by interacting with CD58 (LFA-3) and CD48/BCM1. Implicated in T-cell triggering, its cytoplasmic domain has signaling functions. CD2 also interacts with CD2AP and PSTPIP1. Moreover, its interaction with FCGR3A modulates NK cell activation and cytotoxicity. CD2 Protein, Cynomolgus (HEK293, His, solution) is the recombinant cynomolgus-derived CD2 protein, expressed by HEK293 , with C-His labeled tag. The total length of CD2 Protein, Cynomolgus (HEK293, His, solution) is 185 a.a., with molecular weight of ~35.7 kDa.
CD2 Protein mediates T-cell adhesion to other cell types by interacting with CD58 (LFA-3) and CD48/BCM1. Implicated in T-cell triggering, its cytoplasmic domain has signaling functions. CD2 also interacts with CD2AP and PSTPIP1. Moreover, its interaction with FCGR3A modulates NK cell activation and cytotoxicity. CD2 Protein, Cynomolgus (HEK293, C-His) is the recombinant cynomolgus-derived CD2 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of CD2 Protein, Cynomolgus (HEK293, C-His) is 185 a.a., with molecular weight of ~33.91 kDa.
TREM-2 Protein binds to DAP10 activates the PI3K signaling pathway. TREM2 signaling leads to downregulated transcription of genes that promote inflammation (Tnf, Il1b, and Nos2), as well as release of cytokines that prevent activation of anti-tumor CD8+ T cells. In addition, it signaling can antagonize TLR expression and signaling, resulting in reduced production of inflammatory cytokines by cultured mouse macrophages. The neuroprotective effects of TREM2 involve not only production of anti-inflammatory cytokines, but also clearance of abnormal proteins and phagocytosis of apoptotic neurons. TIM-3/HAVCR2 Protein, Cynomolgus (HEK293, Fc) is the recombinant cynomolgus-derived TIM-3/HAVCR2 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of TIM-3/HAVCR2 Protein, Cynomolgus (HEK293, Fc) is 201 a.a., with molecular weight of ~60.5 & 35.8 kDa, respectively.
IL-9 is secreted by T helper 2 lymphocytes, mast cells, and NKT cells and plays an important role in antiparasitic immune responses, affecting intestinal permeability, adaptive immunity, and T cell subset differentiation. It promotes TH17 cell and mast cell proliferation through IL9R and IL2RG receptor activation, triggering JAK1 and JAK3 kinases and subsequent STAT-mediated transcription. IL-9 Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived IL-9 protein, expressed by HEK293 , with C-His labeled tag. The total length of IL-9 Protein, Cynomolgus (HEK293, His) is 126 a.a., with molecular weight of 25-30 kDa.
CD8 alpha is an important immune glycoprotein that serves as a coreceptor for MHC class I:peptide complexes, linking T cells to antigens presented by APCs. It interacts with TCR and MHC class I, recruits LCK kinase, and initiates multiple signaling pathways. CD8 alpha Protein, Cynomolgus (HEK293, Fc) is the recombinant cynomolgus-derived CD8 alpha protein, expressed by HEK293 , with C-hFc labeled tag. The total length of CD8 alpha Protein, Cynomolgus (HEK293, Fc) is 182 a.a., with molecular weight of ~44.4 kDa.
The CD28 protein is critical for T cell activation, enhancing proliferation, cytokine production, and survival. When linked to TCR/CD3 and CD40L, CD28 promotes the production of IL4 and IL10, thereby regulating immune responses. CD28 Protein, Cynomolgus/Rhesus Macaque (HEK293, His) is the recombinant Rhesus Macaque, cynomolgus-derived CD28 protein, expressed by HEK293 , with C-His labeled tag. The total length of CD28 Protein, Cynomolgus/Rhesus Macaque (HEK293, His) is 134 a.a., with molecular weight of 27-45 kDa.
ALCAM/CD166 Protein is a glycoprotein involved in homotypic and heterotypic cell adhesion. ALCAM/CD166 has emerged as a modulator of cancer progression, mainly by controlling cell proliferation, adhesion, migration and invasion. ALCAM/CD166 Protein, Cynomolgus (HEK293, Fc) is the recombinant cynomolgus-derived ALCAM/CD166 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of ALCAM/CD166 Protein, Cynomolgus (HEK293, Fc) is 526 a.a., with molecular weight of ~82.9 KDa.
ALCAM/CD166 Protein is a glycoprotein involved in homotypic and heterotypic cell adhesion. ALCAM/CD166 has emerged as a modulator of cancer progression, mainly by controlling cell proliferation, adhesion, migration and invasion. ALCAM/CD166 Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived ALCAM/CD166 protein, expressed by HEK293 , with C-His labeled tag. The total length of ALCAM/CD166 Protein, Cynomolgus (HEK293, His) is 499 a.a., with molecular weight of ~75-95 kDa.
IL-4 protein has an important effect on B cell activation, acting as a costimulator for DNA synthesis and promoting the expression of class II MHC molecules on resting B cells. It enhances IgE and IgG1 secretion and cell surface expression while also regulating CD23 expression on lymphocytes and monocytes. IL-4 Protein, Cynomolgus (P.pastoris, His) is the recombinant cynomolgus-derived IL-4 protein, expressed by P. pastoris , with N-His labeled tag. The total length of IL-4 Protein, Cynomolgus (P.pastoris, His) is 129 a.a., with molecular weight of ~16.9 kDa.
TREM-2 Protein is an immune receptor expressed on immune and non-immune cells. It is an anti-inflammatory molecule and considered a marker for microglia activation. CD1E-B2M Heterodimer Protein, Cynomolgus (HEK293, His) is a recombinant protein dimer complex containing cynomolgus-derived CD1E-B2M Heterodimer protein, expressed by HEK293 , with N-His labeled tag. CD1E-B2M Heterodimer Protein, Cynomolgus (HEK293, His), has molecular weight of ~37.8 & 13.6 kDa, respectively.
FOLR1 is a folic acid receptor that binds to folic acid and reductive folic acid derivatives and promotes the entry of 5-methyltetrahydrofolate and folate analogs into the cell interior. FOLR1 enhances the stability and nuclear translocation of β-catenin through the EGFR/AKT/GSK3β axis, thereby promoting the proliferation and migration of laryngeal squamous cell carcinoma (LSCC). FOLR1 is highly expressed in a variety of tumors and is a potential prognostic and therapeutic target for many cancers. FOLR1 Protein, Cynomolgus/Rhesus Macaque (209a.a, HEK293, His) is the recombinant cynomolgus, Rhesus Macaque-derived FOLR1 protein, expressed by HEK293 , with C-His labeled tag.
PD-1 is a cell surface receptor on T and B cells that binds to PD-L1 and PD-L2. PD-1 is an immune checkpoint that protects autoimmunity by promoting apoptosis of antigen-specific T cells in lymph nodes (programmed cell death) and reducing apoptosis of regulatory T cells (anti-inflammatory, inhibitory T cells). The expression of PD-L1 on tumor cells inhibits anti-tumor activity through the binding of PD-1 to effector T cells. PD-1 Protein, Cynomolgus (Biotinylated, 143a.a, HEK293, Fc-Avi) is the recombinant cynomolgus-derived PD-1 protein, expressed by HEK293 , with C-Avi, C-hFc labeled tag. The total length of PD-1 Protein, Cynomolgus (Biotinylated, 143a.a, HEK293, Fc-Avi) is 143 a.a., with molecular weight of ~44.5 kDa.
NKp80/KLRF1 Protein plays a pivotal role in the natural killer (NK)-mediated cytolysis of PHA-induced lymphoblasts, highlighting its significance in immune response. As a homodimer, it structurally arranges in cells. Its involvement in NK-mediated cytolysis contributes to the immune system's ability to eliminate specific cell populations, enhancing cellular defense mechanisms. NKp80/KLRF1 Protein, Cynomolgus (HEK293, Fc) is the recombinant cynomolgus-derived NKp80/KLRF1 protein, expressed by HEK293 , with N-hFc labeled tag. The total length of NKp80/KLRF1 Protein, Cynomolgus (HEK293, Fc) is 166 a.a., with molecular weight of ~53-75 kDa.
EPCR Protein plays a pivotal role in blood coagulation by binding to and enhancing the activation of protein C through interaction with the thrombin-thrombomodulin complex. Its significance lies in regulating coagulation processes and modulating protein C activation, a crucial factor in anticoagulant mechanisms. EPCR Protein, Cynomolgus (HEK293, Fc) is the recombinant cynomolgus-derived EPCR protein, expressed by HEK293 , with C-hFc labeled tag. The total length of EPCR Protein, Cynomolgus (HEK293, Fc) is 209 a.a., with molecular weight of 58-68 kDa.
EPCR Protein plays a pivotal role in blood coagulation by binding to and enhancing the activation of protein C through interaction with the thrombin-thrombomodulin complex. Its significance lies in regulating coagulation processes and modulating protein C activation, a crucial factor in anticoagulant mechanisms. EPCR Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived EPCR protein, expressed by HEK293 , with C-His labeled tag. The total length of EPCR Protein, Cynomolgus (HEK293, His) is 192 a.a., with molecular weight of 30-47 kDa.
PDCD1LG2 is an immune checkpoint receptor ligand that binds to PD-1 to activate pathways that inhibit TCR/ BCR-mediated immune cell activation. PDCD1LG2 can inhibit T-cell proliferation and inflammatory cytokine production. The expression of PDCD1LG2 on mouse tumor cells inhibits cytotoxic T-cell-mediated immune responses and can be used as a biomarker or prognostic indicator. PD-L2 Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived PD-L2 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of PD-L2 Protein, Cynomolgus (HEK293, His) is 200 a.a., with molecular weight of 30-40 kDa.
B Cell Maturation Antigen (BCMA) also referred to as TNFRSF17 or CD269, is a transmembrane glycoprotein member of the tumor necrosis factor receptor (TNFR) superfamily. BCMA is used as a biomarker for Multiple myeloma (MM). BCMA mainly plays an important role in B cells for their proliferation, survival and also differentiates them into plasma cells. BCMA/TNFRSF17 Protein, Cynomolgus (HEK293, His) is a recombinant protein with a C-Terminal His label, It consists of 53 amino acids (M1-A53) and is produced in HEK293 cells.
IL-4 protein has an important effect on B cell activation, acting as a costimulator for DNA synthesis and promoting the expression of class II MHC molecules on resting B cells. It enhances IgE and IgG1 secretion and cell surface expression while also regulating CD23 expression on lymphocytes and monocytes. IL-4 Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived IL-4 protein, expressed by HEK293 , with C-His labeled tag. The total length of IL-4 Protein, Cynomolgus (HEK293, His) is 129 a.a., with molecular weight of 23-28 kDa.
The CD28 protein is critical for T cell activation, enhancing proliferation, cytokine production, and survival. When linked to TCR/CD3 and CD40L, CD28 promotes the production of IL4 and IL10, thereby regulating immune responses. CD28 Protein, Human/Cynomolgus (Biotinylated, HEK293, Fc-Avi) is the recombinant human, cynomolgus-derived CD28 protein, expressed by HEK293 , with C-Avi, C-hFc labeled tag. The total length of CD28 Protein, Human/Cynomolgus (Biotinylated, HEK293, Fc-Avi) is 134 a.a., with molecular weight of 60-90 kDa.
CD20/MS4A1 protein is a B lymphocyte membrane protein that plays a crucial regulatory role in cellular calcium influx, which is essential for the development, differentiation and activation of B lymphocytes. As part of a store-operated calcium (SOC) channel, it promotes calcium influx upon B cell receptor/BCR activation. CD20/MS4A1 Protein, Cynomolgus (85a.a, HEK293, His) is the recombinant cynomolgus-derived CD20/MS4A1 protein, expressed by HEK293 , with C-His labeled tag. The total length of CD20/MS4A1 Protein, Cynomolgus (85a.a, HEK293, His) is 85 a.a., with molecular weight of 22.66 & 24.28 kDa, respectively.
The CD28 protein is critical for T cell activation, enhancing proliferation, cytokine production, and survival. When linked to TCR/CD3 and CD40L, CD28 promotes the production of IL4 and IL10, thereby regulating immune responses. CD28 Protein, Human/Cynomolgus (HEK293, mFc) is the recombinant cynomolgus-derived CD28 protein, expressed by HEK293 , with N-mFc labeled tag. The total length of CD28 Protein, Human/Cynomolgus (HEK293, mFc) is 134 a.a., with molecular weight of 65-68 kDa.
4-1BB (CD137; TNFRSF9), is a surface glycoprotein, a receptor of TNFSF9/4-1BBL, belongs to the tumor necrosis factor (TNF) receptor superfamily. 4-1BB is helpful for T cell activation and development, and also induces peripheral mononuclear cell proliferation and migration to the tumor microenvironment. 4-1BB is also involved in enhancing Nrf2 and NF-κB pathway mediated apoptosis of endothelial cells. 4-1BB/TNFRSF9 Protein, Cynomolgus/Rhesus Macaque (HEK293, His) has 163 amino acids (L24-Q186), produced by HEK293 cells with C-terminal His-tag.
B Cell Maturation Antigen (BCMA) also referred to as TNFRSF17 or CD269, is a transmembrane glycoprotein member of the tumor necrosis factor receptor (TNFR) superfamily. BCMA is used as a biomarker for Multiple myeloma (MM). BCMA mainly plays an important role in B cells for their proliferation, survival and also differentiates them into plasma cells. BCMA/TNFRSF17 Protein, Cynomolgus (HEK293, Fc) is a recombinant protein with a C-Terminal Fc label, It consists of 53 amino acids (M1-A53) and is produced in HEK293 cells.
T-CELl immunoreceptor with Ig and ITIM domains; VSIG9; VSTM3; TIGIT; V-set and transmembrane domain-containing protein 3; V-set and immunoglobulin domain-containing protein 9
Ig-like domain-containing protein is a class of proteins that may be involved in protein–protein and protein–ligand interactions, therefore being involved in biological processes such as down-regulation of T cell activation or cardiac and neuronal development. TIGIT Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived TIGIT protein, expressed by HEK293 , with C-6*His labeled tag. The total length of TIGIT Protein, Cynomolgus (HEK293, His) is 121 a.a., with molecular weight of 16-30 kDa.
PDCD1LG2 is an immune checkpoint receptor ligand that binds to PD-1 to activate pathways that inhibit TCR/ BCR-mediated immune cell activation. PDCD1LG2 can inhibit T-cell proliferation and inflammatory cytokine production. The expression of PDCD1LG2 on mouse tumor cells inhibits cytotoxic T-cell-mediated immune responses and can be used as a biomarker or prognostic indicator. PD-L2 Protein, Cynomolgus (HEK293, Fc) is the recombinant cynomolgus-derived PD-L2 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of PD-L2 Protein, Cynomolgus (HEK293, Fc) is 200 a.a., with molecular weight of 60-90 kDa.
T-CELl immunoreceptor with Ig and ITIM domains; VSIG9; VSTM3; TIGIT; V-set and transmembrane domain-containing protein 3; V-set and immunoglobulin domain-containing protein 9
Ig-like domain-containing protein is a class of proteins that may be involved in protein–protein and protein–ligand interactions, therefore being involved in biological processes such as down-regulation of T cell activation or cardiac and neuronal development. TIGIT Protein, Cynomolgus (HEK293, C-hFc) is the recombinant cynomolgus-derived TIGIT protein, expressed by HEK293 , with C-hFc labeled tag. The total length of TIGIT Protein, Cynomolgus (HEK293, C-hFc) is 121 a.a., with molecular weight of 45-55 kDa.
CD274 molecule, also known as programmed death ligand 1 (PD-L1), binds to the checkpoint suppressor molecule PD-1 to inhibit TCR-mediated IL-2 production and T cell proliferation signaling. PD-L1 is involved in the PI3K/JAK/STAT signaling pathway to promote tumor occurrence. PD-L1 Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived PD-L1 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of PD-L1 Protein, Cynomolgus (HEK293, His) is 221 a.a., with molecular weight of 32-40 kDa.
CD274 molecule, also known as programmed death ligand 1 (PD-L1), binds to the checkpoint suppressor molecule PD-1 to inhibit TCR-mediated IL-2 production and T cell proliferation signaling. PD-L1 is involved in the PI3K/JAK/STAT signaling pathway to promote tumor occurrence. PD-L1 Protein, Cynomolgus (HEK293, Fc) is the recombinant cynomolgus-derived PD-L1 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of PD-L1 Protein, Cynomolgus (HEK293, Fc) is 221 a.a., with molecular weight of ~73.0 kDa.
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