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TNFSF12

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  • HY-P77263
    TWEAK/TNFSF12 Protein, Human/Cynomolgus (HEK293, mFc)

    Tumor necrosis factor ligand superfamily member 12; TWEAK; APO3L; DR3LG

    		 Human;Cynomolgus HEK293
    TWEAK Protein refers to the cytokine tumor necrosis factor-like weak inducer of apoptosis, belongs to tumor necrosis factor (TNF) superfamily. TWEAK protein binds to FN14 and TNRFSF12/APO3, is a weak inducer of apoptosis. TWEAK does have pro-apoptotic activity for tumor cell, mediates NF-kappa-B activation, promotes angiogenesis and the proliferation of endothelial cells (ECs). TWEAK also increases IL-6 and IL-8 secretion, and could potentiate the pro-inflammatory activities of TNF and IL-1.TWEAK/TNFSF12 Protein, Human/Cynomolgus (HEK293, mFc) is the extracellular part (S97-H249) of TWEAK protein, produced by HEK293 cells with N-terminal mFc-tag.

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