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17-Phenyl trinor PGF2α

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Biochemical Assay Reagents (1) Drug Derivative (3) Drug Intermediate (1) Drug Isomer (1) Isotope-Labeled Compounds (1) Prostaglandin Receptor (9)
By Research Areas:	Cardiovascular Disease (2) Endocrinology (6) Metabolic Disease (1) Neurological Disease (1)

Inhibitors & Agonists

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-125774

Bimatoprost acid 17-Phenyl trinor PGF2α	Prostaglandin Receptor	Others
Bimatoprost acid (17-Phenyl trinor PGF2α), the acid hydrolysis product of Bimatoprost (HY-B0191), is a potent agonist of prostaglandin FP receptor .

HY-116161A

17-Phenyl trinor PGF2α isopropyl ester	Prostaglandin Receptor	Metabolic Disease
17-Phenyl trinor PGF₂α isopropyl ester is a FP receptor agonist and intraocular pressure-lowering agent. 17-Phenyl trinor PGF₂α isopropyl ester induces iris sphincter contraction, reduces intraocular pressure and pupil diameter, causes no ocular irritation, and only leads to mild conjunctival hyperemia. 17-Phenyl trinor PGF₂α isopropyl ester is applicable to relevant research on glaucoma .

HY-125774S

Bimatoprost acid-d4 17-Phenyl trinor PGF2α-d₄	Isotope-Labeled Compounds	Others
Bimatoprost acid-d₄ (17-Phenyl trinor PGF2α-d₄) is the deuterium labeled Bimatoprost acid .

HY-W746888

17-Phenyl trinor prostaglandin F2α diethyl amide 17-p-PGF2α-NEt2; 17-Phenyl trinor PGF2α diethyl amide	Prostaglandin Receptor	Cardiovascular Disease
17-Phenyl trinor prostaglandin F2α diethyl amide (17-phenyl trinor PGF2α diethyl amide) is a *PGF_2α* analog with hypotensive efficacy .

HY-176014

17-Phenyl trinor prostaglandin F2α glycinamide 17-Phenyl trinor PGF2α glycinamide	Drug Derivative	Others
17-phenyl trinor PGF2α glycinamide (17-Phenyl trinor PGF2α glycinamide) is a derivative of 17-phenyl trinor prostaglandin F2α ethyl amide .

HY-W746889

17-Phenyl trinor prostaglandin F2α 1,15-lactone 17-Phenyl trinor PGF2α 1,15-lactone	Drug Derivative	Others
17-Phenyl trinor prostaglandin F2α 1,15-lactone (17-Phenyl trinor PGF2α 1,15-lactone) is a 1,15 lactone of 17-Phenyl trinor prostaglandin F2α. 17-Phenyl trinor prostaglandin F2α is a metabolite of Dinoprost (HY-12956) .

HY-114867

(15R)-Bimatoprost 15(R)-17-Phenyl trinor PGF2α ethyl amide	Prostaglandin Receptor	Endocrinology
(15R)-Bimatoprost (15(R)-17-phenyl trinor PGF2α ethyl amide) is a prostaglandin analog used to study glaucoma and ocular hypertension. (15R)-Bimatoprost is an isomer of Bimatoprost with an inverted (β) hydroxyl group on C-15 .

HY-176096

1α-Monohomo-17-phenyl trinor Prostaglandin F2α 1α-Monohomo-17-Phenyl trinor PGF2α	Biochemical Assay Reagents	Others
1α-Monohomo-17-phenyl trinor Prostaglandin F2α (1α-Monohomo-17-phenyl trinor PGF2α) is a derivative of 17-phenyl trinor prostaglandin F2α ethyl amide. 1α-Monohomo-17-phenyl trinor Prostaglandin F2α is also an isomer of 17-phenyl trinor prostaglandin F2α methyl ester.

HY-113778

15-keto-17-phenyl trinor Prostaglandin F2α 15-keto-17-Phenyl trinor PGF2α	Prostaglandin Receptor	Endocrinology
15-keto-17-phenyl trinor Prostaglandin F2α (15-keto-17-phenyl trinor PGF2α) is an F-series prostaglandin (PG) analog. The potential metabolite of 15-keto-17-phenyl trinor Prostaglandin F2α in animals is 15-keto PG. 15-keto PG can slightly reduce the intraocular pressure (1 mm Hg) in normal cynomolgus monkeys when administered at a dose of 1 μg/eye. 15-keto-17-phenyl trinor Prostaglandin F2α is a miotic agent in cats, reducing the pupil diameter by 8 mm at a dose of 5 μg/eye.

HY-172574

8-iso-17-Phenyl trinor prostaglandin F2α 8-iso-17-Phenyl trinor PGF2α	Drug Isomer Drug Derivative	Neurological Disease
8-Iso-17-phenyl trinor prostaglandin F2α (8-Iso-17-phenyl trinor PGF2), the C-8 epimer of Bimatoprost (HY-B0191), is a PGF_2α (HY-12956) analog. Bimatoprost can be used in the research of glaucoma and high intraocular pressure.

HY-116161

Bimatoprost isopropyl ester	Drug Intermediate	Cardiovascular Disease Others
15(R)-17-phenyl trinor Prostaglandin F2α isopropyl ester (15(R)-17-phenyl trinor PGF2α isopropyl ester) is the latanoprost-related isomer containing both a double bond at 13,14 and an inverted (β) hydroxyl group at C-15. Similar to 15(S)-latanoprost, 15(R)-17-phenyl trinor PGF2α isopropyl ester is a potential impurity in most commercial preparations of the latanoprost bulk drug product. The IC₅₀ values for the free acid forms of 15(S)-17-phenyl trinor PGF2α and 15(R)-17-phenyl trinor PGF2α were determined to be 0.71 nM and 30 nM, respectively, in a FP receptor binding assay using the cat iris sphincter muscle.1 A 3 μg dose of 15(R)-17-phenyl trinor PGF2α caused a 1.9 mmHg reduction of IOP in normotensive cynomolgus monkeys.

HY-116679

17-trifluoromethylphenyl trinor Prostaglandin F2α 17-TrifluoromethylPhenyl trinor PGF2α	Prostaglandin Receptor	Endocrinology
A number of 17-phenyl trinor prostaglandin F2α (17-phenyl trinor PGF2α) derivatives have been approved for glaucoma. Of these, the unsubstituted or meta-substituted aromatic derivatives are the most potent FP receptor agonists.4 17-trifluoromethylphenyl trinor PGF2α bears an aromatic ring which is reminiscent of the trifluoromethyl-phenoxy ring of travoprost ((+)-fluprostenol isopropyl ester). As an ocular hypotensive agent, it would be expected that 17-trifluoromethylphenyl trinor PGF2α would act very much like the free acid of travoprost. 17-phenyl trinor PGF2α is a potent luteolytic, with a potency equal to or greater than fluprostenol and cloprostenol.

HY-176011

17-Phenyl trinor prostaglandin F2α glycinamide methyl ester 17-Phenyl trinor PGF2α glycinamide methyl ester	Prostaglandin Receptor	Endocrinology
17-Phenyl trinor prostaglandin F2α glycinamide methyl ester is a derivative of Bimatoprost (HY-B0191) and a prostaglandin analog. 17-Phenyl trinor prostaglandin F2α glycinamide methyl ester is a human prostaglandin FP receptor agonist. 17-Phenyl trinor prostaglandin F2α glycinamide methyl ester has an ocular hypotensive effect and can be used in the study of ocular hypertension and glaucoma .

HY-158782

5-trans Bimatoprost acid	Others	Others
5-trans-17-phenyl trinor Prostaglandin F2α (5-trans-17-phenyl trinor PGF2α) is the 5-trans isomer of HY-B0191 Bimatoprost (17-phenyl trinor PGF2α).

HY-120197

17-Phenyl trinor prostaglandin F2α methyl amide	Prostaglandin Receptor	Endocrinology
17-Phenyl trinor prostaglandin F2α methyl amide is a prostaglandin F 2α (PGF 2α) analog that competes with native PGF 2α for receptor binding .

HY-139121

15(R)-17-Phenyl trinor Prostaglandin F2α 15-epi Bimatoprost free acid; 15(R)-Bimatoprost free acid; 15(R)-17-Phenyl trinor PGF2α	Prostaglandin Receptor	Endocrinology
15(R)-17-Phenyl trinor Prostaglandin F2α (15-epi Bimatoprost free acid) is a prostaglandin F (FP) analog that acts as an ocular hypotensive agent. The free acid 17-Phenyl trinor Prostaglandin F2α is a potent FP receptor agonist. 15(R)-17-Phenyl trinor Prostaglandin F2α is the 15-epi or "unnatural" isomer of this active free acid metabolite and has reduced FP receptor agonist activity.

Bimatoprost acid-d4
Bimatoprost acid-d₄ (17-Phenyl trinor PGF2α-d₄) is the deuterium labeled Bimatoprost acid .

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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