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Results for "

26-L5

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Adenosine Kinase (1) Apoptosis (2) Bacterial (1) Biochemical Assay Reagents (2) Cathepsin (1) G-quadruplex (1) MicroRNA (8) Small Interfering RNA (siRNA) (1) VEGFR (1)
By Research Areas:	Cancer (9) Infection (1) Inflammation/Immunology (1)

Inhibitors & Agonists

Biochemical Assay Reagents

Natural
Products

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N1622

1-Dehydroxy-23-deoxojessic acid	Others	Cancer
1-Dehydroxy-23-deoxojessic acid (compound 10) is a cycloartane-type triterpene. 1-Dehydroxy-23-deoxojessic acid exhibits cytotoxicity against murine colon 26-L5 carcinoma cells, with an EC₅₀ of 62.38 μM .

HY-N0998

1,7-Bis(4-hydroxyphenyl)-hepta-4E,6E-dien-3-one	Others	Cancer
1,7-Bis(4-hydroxyphenyl)-hepta-4E,6E-dien-3-one (compound 6) shows antiproliferative activity with ED₅₀s of 57.7, 78.8 µM for 26-L5 and HT-1080 cells, respectively. 1,7-Bis(4-hydroxyphenyl)-hepta-4E,6E-dien-3-one inhibits melanogenesis in B16 melanoma 4A5 cells. 1,7-Bis(4-hydroxyphenyl)-hepta-4E,6E-dien-3-one has the potential for the research of skin disorders .

HY-N8398

n-Octyl caffeate

Apoptosis Cancer

n-Octyl caffeate shows anti-cancer and apoptosis inducing activity in highly liver-metastatic murine colon 26-L5 carcinoma cell lines .

n-Octyl caffeate	Apoptosis	Cancer
n-Octyl caffeate shows anti-cancer and apoptosis inducing activity in highly liver-metastatic murine colon 26-L5 carcinoma cell lines .

HY-N10158

1,7-Bis(4-hydroxyphenyl)-3-hydroxy-1,3-heptadien-5-one	Others	Cancer
1,7-Bis(4-hydroxyphenyl)-3-hydroxy-1,3-heptadien-5-one (compound 39), a diarylheptanoid, exhibits antiproliferative activity towards human HT-1080 fibrosarcoma and murine colon 26-L5 carcinoma cells .

HY-R00495

*hsa-miR-26a-5p mimic*	MicroRNA	Cancer
hsa-miR-26a-5p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.

hsa-miR-26a-5p mimic hsa-miR-26a-5p mimic

HY-RS13139

SLC26A5 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
SLC26A5 Human Pre-designed siRNA Set A contains three designed siRNAs for SLC26A5 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

SLC26A5 Human Pre-designed siRNA Set A SLC26A5 Human Pre-designed siRNA Set A

HY-R00497

*hsa-miR-26b-5p mimic*	MicroRNA	Cancer
hsa-miR-26b-5p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.

hsa-miR-26b-5p mimic hsa-miR-26b-5p mimic

HY-RI00495

*hsa-miR-26a-5p inhibitor*	MicroRNA
hsa-miR-26a-5p inhibitors are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA inhibitors have full-length nucleotide 2'-methoxy modification. The miRNA inhibitors strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning.

hsa-miR-26a-5p inhibitor hsa-miR-26a-5p inhibitor

HY-RI00497

*hsa-miR-26b-5p inhibitor*	MicroRNA
hsa-miR-26b-5p inhibitors are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA inhibitors have full-length nucleotide 2'-methoxy modification. The miRNA inhibitors strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning.

hsa-miR-26b-5p inhibitor hsa-miR-26b-5p inhibitor

HY-R00495A

*hsa-miR-26a-5p agomir*	MicroRNA
hsa-miR-26a-5p agomirs are chemically-modified double-strand miRNA mimics with modified mature miRNA strand: 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 3' end cholesterol group, and full-length nucleotide 2'-methoxy modification. They are designed to mimic endogenous miRNAs and recommended for miRNA functional studies. Compared with miRNA mimics, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

hsa-miR-26a-5p agomir hsa-miR-26a-5p agomir

HY-R00497A

*hsa-miR-26b-5p agomir*	MicroRNA
hsa-miR-26b-5p agomirs are chemically-modified double-strand miRNA mimics with modified mature miRNA strand: 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 3' end cholesterol group, and full-length nucleotide 2'-methoxy modification. They are designed to mimic endogenous miRNAs and recommended for miRNA functional studies. Compared with miRNA mimics, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

hsa-miR-26b-5p agomir hsa-miR-26b-5p agomir

HY-W002688

2,6-Dichloro-5-fluoronicotinic acid	Biochemical Assay Reagents	Others
2,6-Dichloro-5-fluoropyridine-3-carboxylic acid is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-RI00495A

*hsa-miR-26a-5p antagomir*	MicroRNA
hsa-miR-26a-5p antagomirs are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA antagomirs have 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 1 cholesterol group at the 3' end, and full-length nucleotide 2'-methoxy modification. The miRNA antagomirs strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning. Stability of miRNA antagomirs appears to be significantly higher than miRNA inhibitors, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

hsa-miR-26a-5p antagomir hsa-miR-26a-5p antagomir

HY-RI00497A

*hsa-miR-26b-5p antagomir*	MicroRNA
hsa-miR-26b-5p antagomirs are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA antagomirs have 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 1 cholesterol group at the 3' end, and full-length nucleotide 2'-methoxy modification. The miRNA antagomirs strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning. Stability of miRNA antagomirs appears to be significantly higher than miRNA inhibitors, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

hsa-miR-26b-5p antagomir hsa-miR-26b-5p antagomir

HY-W145609

Neu5Troc[1Me,4789Ac]α(2-3)Gal[26Bn]-β-MP	Biochemical Assay Reagents	Others
Neu5Troc[1Me,4789Ac]α(2-3)Gal[26Bn]-β-MP is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-136638

ML328	Bacterial	Infection
ML328 is a selective inhibitor of bacterial AddAB and RecBCD helicase-nucleases with IC₅₀ values of 26 and 5.1 μM, respectively. ML328 is a gyrase inhibitor. ML328 strongly inhibits the growth of E. coli in the presence of phage. ML328 can be used for the research of bacterial infection .

HY-146230

VEGFR-2-IN-26	VEGFR	Cancer
VEGFR-2-IN-26 (compound 5h) is a highly potent VEGFR-2 inhibitor with an IC₅₀ value of 15.5 nM. VEGFR-2-IN-26 has good antiproliferative activity against the leukemic, non-small lung, CNS, ovarian, renal, prostate and breast cancer cells .

HY-15424

5-Iodotubercidin 5+ Cited Publications NSC 113939; 5-ITu	Adenosine Kinase	Cancer
5-Iodotubercidin (NSC 113939), an ATP mimetic, is a potent adenosine kinase inhibitor with an IC₅₀ of 26 nM. 5-Iodotubercidin (NSC 113939) initiates glycogen synthesis in isolated hepatocytes by causing inactivation of phosphorylase and activation of glycogen synthase. 5-Iodotubercidin (NSC 113939) also inhibits CK1, insulin receptor tyrosine kinase, phosphorylase kinase, PKA, CK2, PKC and Haspin .

HY-144712

L5-DA	G-quadruplex Apoptosis	Cancer
L5-DA is a G-quadruplex (G4) ligand and selectively stabilized for G4s over ds26. L5-DA exhibits significant cytotoxicity against HeLa cells (IC₅₀=4.3 μM). L5-DA stabilizes G4s in HeLa cells, induces apoptosis, and cell cycle arrest .

HY-146584

Cathepsin C-IN-5	Cathepsin	Inflammation/Immunology
Cathepsin C-IN-5 (compound SF38) is a potent, selective and orally active Cathepsin C inhibitor with IC₅₀s of 59.9 nM, 4.26 µM, >5 µM, >5 µM, >5 µM for Cat C, Cat L, Cat S, Cat B, Cat K, respectively. Cathepsin C-IN-5 inhibits the Cat C activity in bone marrow and blood. Cathepsin C-IN-5 decreases the activation of NSPs (neutrophil serine proteases). Cathepsin C-IN-5 shows anti-inflammatory activity .

2,6-Dichloro-5-fluoronicotinic acid	Biochemical Assay Reagents
2,6-Dichloro-5-fluoropyridine-3-carboxylic acid is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

Neu5Troc[1Me,4789Ac]α(2-3)Gal[26Bn]-β-MP	Biochemical Assay Reagents
Neu5Troc[1Me,4789Ac]α(2-3)Gal[26Bn]-β-MP is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

1-Dehydroxy-23-deoxojessic acid	Triterpenes Combretaceae Source classification Plants Combretum quadrangulare Kurz	Others
1-Dehydroxy-23-deoxojessic acid (compound 10) is a cycloartane-type triterpene. 1-Dehydroxy-23-deoxojessic acid exhibits cytotoxicity against murine colon 26-L5 carcinoma cells, with an EC₅₀ of 62.38 μM .

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