1,7-Bis(4-hydroxyphenyl)-hepta-4E,6E-dien-3-one
Based on 1 Customer Validation
1,7-Bis(4-hydroxyphenyl)-hepta-4E,6E-dien-3-one (compound 6) shows antiproliferative activity with ED50s of 57.7, 78.8 μM for 26-L5 and HT-1080 cells, respectively. 1,7-Bis(4-hydroxyphenyl)-hepta-4E,6E-dien-3-one inhibits melanogenesis in B16 melanoma 4A5 cells. 1,7-Bis(4-hydroxyphenyl)-hepta-4E,6E-dien-3-one has the potential for the research of skin disorders.
For research use only. We do not sell to patients.
- Purity : 97%
- CAS No.: 332371-82-1
- Formula: C19H18O3
- Molecular Weight:294.34
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Storage:
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| B16-4A5 | IC50 |
1.99 μM
Compound: 2
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Antimelanogenic activity in mouse B16-4A5 cells assessed as inhibition of theophylline-induced melanin production after 72 hrs by spectrophotometry relative to control
Antimelanogenic activity in mouse B16-4A5 cells assessed as inhibition of theophylline-induced melanin production after 72 hrs by spectrophotometry relative to control
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[PMID: 23910596] |
| HT-1080 | ED50 |
78.8 μM
Compound: 6
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Antiproliferative activity against human HT1080 cells by MTT assay
Antiproliferative activity against human HT1080 cells by MTT assay
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[PMID: 11277741] |
| NCI-H460 | IC50 |
>50 μM
Compound: 10
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Cytotoxicity against human NCI-H460 cells incubated for 24 hrs by MTT assay
Cytotoxicity against human NCI-H460 cells incubated for 24 hrs by MTT assay
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[PMID: 28606759] |
| RAW264.7 | IC50 |
4.79 μM
Compound: 11
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Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production by MTT assay
Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production by MTT assay
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[PMID: 20879743] |
In Vitro
Chemical Information
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CAS No. 332371-82-1
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Appearance Solid
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Molecular Weight 294.34
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Formula C19H18O3
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Color Light yellow to yellow
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SMILES
O=C(/C=C/C=C/C1=CC=C(O)C=C1)CCC2=CC=C(O)C=C2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Purity & Documentation
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Data Sheet (264 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Ali MS, et al. Six new diarylheptanoids from the seeds of Alpinia blepharocalyx. J Nat Prod. 2001 Mar;64(3):289-93. [Content Brief]
[2]. Matsumoto T, et al. Diarylheptanoids with inhibitory effects on melanogenesis from the rhizomes of Curcuma comosa in B16 melanoma cells. Bioorg Med Chem Lett. 2013 Sep 15;23(18):5178-81. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
1,7-Bis(4-hydroxyphenyl)-hepta-4E,6E-dien-3-one Related Classifications
HY-N0998 Related Classifications
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