332371-82-1
332371-82-1
Chemical Structure
1,7-Bis(4-hydroxyphenyl)-hepta-4E,6E-dien-3-one
- CAS No.: 332371-82-1
- Formula:C19H18O3
- Molecular Weight:294.34
IUPAC Name: (4E,6E)-1,7-bis(4-hydroxyphenyl)hepta-4,6-dien-3-one
InChIKey: QIROPQQWKBMABC-ZPUQHVIOSA-N
SMILES: O=C(/C=C/C=C/C1=CC=C(O)C=C1)CCC2=CC=C(O)C=C2
Biological Activity: 1,7-Bis(4-hydroxyphenyl)-hepta-4E,6E-dien-3-one (compound 6) shows antiproliferative activity with ED50s of 57.7, 78.8 μM for 26-L5 and HT-1080 cells, respectively. 1,7-Bis(4-hydroxyphenyl)-hepta-4E,6E-dien-3-one inhibits melanogenesis in B16 melanoma 4A5 cells. 1,7-Bis(4-hydroxyphenyl)-hepta-4E,6E-dien-3-one has the potential for the research of skin disorders[1][2].
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1,7-Bis(4-hydroxyphenyl)-hepta-4E,6E-dien-3-one | 1,7-Bis(4-hydroxyphenyl)-hepta-4E,6E-dien-3-one (compound 6) shows antiproliferative activity with ED50s of 57.7, 78.8 μM for 26-L5 and HT-1080 cells, respectively. 1,7-Bis(4-hydroxyphenyl)-hepta-4E,6E-dien-3-one inhibits melanogenesis in B16 melanoma 4A5 cells. 1,7-Bis(4-hydroxyphenyl)-hepta-4E,6E-dien-3-one has the potential for the research of skin disorders. | |||||||||||||||||||||
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References
- [1]. Ali MS, et al. Six new diarylheptanoids from the seeds of Alpinia blepharocalyx. J Nat Prod. 2001 Mar;64(3):289-93. [Content Brief]
- [2]. Matsumoto T, et al. Diarylheptanoids with inhibitory effects on melanogenesis from the rhizomes of Curcuma comosa in B16 melanoma cells. Bioorg Med Chem Lett. 2013 Sep 15;23(18):5178-81. [Content Brief]
