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CDK9-IN-32

" in MedChemExpress (MCE) Product Catalog:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-173523
    KI-CDK9d-32

    		PROTACs CDK c-Myc Cancer
    KI-CDK9d-32 is a highly selective and potent CDK9 PROTAC degrader (DC50: 0.89 nM). KI-CDK9d-32 promotes the ubiquitination and degradation of CDK9. KI-CDK9d-32 inhibits the MYC pathway and disrupts nucleolar homeostasis. KI-CDK9d-32 exhibits anticancer activity against acute lymphoblastic leukemia and pancreatic cancer. (Pink: CDK9 ligand (HY-153718); Blue: E3 ligase CRBN ligand (HY-163233); Black: Linker (HY-W011657); E3 ligase CRBN ligand-linker conjugate (HY-173525)) .
    KI-CDK9d-32
  • HY-W259932
    Lenalidomide 5'-piperazine hydrochloride

    		Ligands for E3 Ligase Cancer
    Lenalidomide 5'-piperazine hydrochloride can serve as a Cereblon ligand to recruit CRBN protein. Lenalidomide 5'-piperazine hydrochloride can be linked to target protein ligands via a linker to form PROTAC molecules, such as KI-CDK9d-32 (HY-173523) .
    Lenalidomide 5'-piperazine hydrochloride
  • HY-157980
    CDK9-IN-32

    		CDK Cancer
    CDK9-IN-32 (compound 006-3) is a CDK9 inhibitor .
    CDK9-IN-32
  • HY-153718
    KI-ARv-03

    		Ligands for Target Protein for PROTAC CDK c-Myc Cancer
    KI-ARv-03 is a potent and selective ATP-competitive CDK9 inhibitor with an IC₅₀ of 0.15 μM (at 45 μM ATP), exhibiting over 130-fold selectivity against other CDKs (including CDK1-7). KI-ARv-03 reduces androgen receptor (AR)-driven transcription and proliferation in prostate cancer cells. KI-ARv-03 can be used for leukemia, pancreatic cancer, alveolar rhabdomyosarcoma (ARMS) and castration-resistant prostate cancer (CRPC) research. KI-ARv-03 is a ligand for target protein for PROTAC. KI-ARv-03 can be used to synthesize PROTAC KI-CDK9d-32 (HY-173523) [1][2].
    KI-ARv-03
  • HY-163233
    Lenalidomide 5'-piperazine

    		Ligands for E3 Ligase Cancer
    Lenalidomide 5'-piperazine can serve as a Cereblon ligand to recruit CRBN protein. Lenalidomide 5'-piperazine can be linked to target protein ligands via a linker to form PROTAC molecules, such as KI-CDK9d-32 (HY-173523) .
    Lenalidomide 5'-piperazine
  • HY-173525
    E3 Ligase Ligand-linker Conjugate 180

    		E3 Ligase Ligand-Linker Conjugates Cancer
    E3 Ligase Ligand-linker Conjugate 180 is an E3 ubiquitinase ligand-linker conjugate. E3 Ligase Ligand-linker Conjugate 180 can be used to synthesize KI-CDK9d-32 (HY-173523) .
    E3 Ligase Ligand-linker Conjugate 180

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