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Ebolavirus

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By Targets:	Autophagy (1) Filovirus (5) Histamine Receptor (1) Parasite (1)
By Research Areas:	Cancer (1) Infection (6)

6

Inhibitors & Agonists

3

Inhibitory Antibodies

3

Recombinant Proteins

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

Ansuvimab Ansuvimab-zyk; mAb114	Filovirus	Infection
Ansuvimab (Ansuvimab-zyk) is a recombinant human monoclonal IgG1 antibody that exhibits antiviral activity against Zaire ebolavirus. Ansuvimab binds to the glycoprotein on Zaire ebolavirus to block its entry into host cells .

Atoltivimab REGN3470	Filovirus	Infection
Atoltivimab (REGN3470), or maftivimab/odesivimab (Inmazeb) is the first Food and agent Administration (FDA)-approved monoclonal antibody to target Zaire *ebolavirus (EBOV*s) infection .

Maftivimab REGN3470-3471-3479	Filovirus	Infection
Maftivimab (REGN3470-3471-3479), the inhibitor of Filovirus, is an Food and agent Administration (FDA)-approved agent. Maftivimab, also named as Atoltivimab, Odesivimab (Inmazeb), can be used for research of Zaire ebolavirus infection .

HY-146813

EBOV/MARV-IN-2

Others Infection

EBOV/MARV-IN-2 (compound 13) is an Ebolavirus (EBOV, IC₅₀=0.9 μM) and Marburg virus (MARV, IC₅₀=2.7 μM) inhibitor .

CP19	Histamine Receptor Filovirus	Infection
CP19, a histamine receptor antagonist, is an entry inhibitor against both Ebolavirus (EBOV) and Marburgvirus (MARV) with IC₅₀s of 3.4 μM and 29.5 μM, respectively. CP19 has SI values of 29.4 and 3.4 for EBOV and MARV, respectively. CP19 has antiviral activity .

Retro-2	Filovirus Parasite Autophagy	Infection Cancer
Retro-2 is a selective inhibitor of retrograde protein trafficking at the endosome-trans-Golgi network interface. Retro-2 is an ebolavirus (EBOV) infection inhibitor with an EC₅₀ of 12.2 µM in HeLa cells. Retro-2 induces cell autophagy .

Species:	Virus (3)
Tag:	His (2) Tag Free (1)
Source:	E. coli (3)

Cat. No.	Compare	Product Name	Species	Source

	Ebola virus NP/Nucleoprotein Protein (109a.a, Q5XX08, His) Ebola virus EBOV (Sudan Ebolavirus, strain Gulu) Nucleoprotein / NP Protein (His)	Virus	E. coli
	The Ebola virus NP/nucleoprotein is critical for viral genome protection and replication, forming a helical capsid to protect the genome. The VP35 interaction stabilizes the monomeric NP, maintaining solubility until replication triggers cooperative binding to viral RNA. Ebola virus NP/Nucleoprotein Protein (109a.a, Q5XX08, His) is the recombinant Virus-derived Ebola virus NP/Nucleoprotein protein, expressed by E. coli , with N-His labeled tag. The total length of Ebola virus NP/Nucleoprotein Protein (109a.a, Q5XX08, His) is 109 a.a., with molecular weight of ~14 kDa.

	Ebola virus NP/Nucleoprotein Protein (378a.a, Q5XX08, His) Ebola virus EBOV (Sudan Ebolavirus, strain Gulu) Nucleoprotein / NP (aa361-aa738) Protein (His)	Virus	E. coli
	The Ebola virus NP/nucleoprotein is critical for viral genome protection and replication, forming a helical capsid to protect the genome. The VP35 interaction stabilizes the monomeric NP, maintaining solubility until replication triggers cooperative binding to viral RNA. Ebola virus NP/Nucleoprotein Protein (378a.a, Q5XX08, His) is the recombinant Virus-derived Ebola virus NP/Nucleoprotein protein, expressed by E. coli , with N-His labeled tag. The total length of Ebola virus NP/Nucleoprotein Protein (378a.a, Q5XX08, His) is 378 a.a., with molecular weight of ~44.1 kDa.

	VP40 Protein, Zaire ebolavirus VP40; Matrix protein VP40; Ebola VP40; eVP40; Membrane-associated protein VP40	Virus	E. coli
	The VP40 protein is critical in viral assembly and interacts with viral ribonucleocapsid and host ESCRT proteins (VPS4, PDCD6IP/ALIX, NEDD4, TSG101). It promotes efficient budding and binds to the host E3 ubiquitin ligase SMURF2. VP40 Protein, Zaire ebolavirus is the recombinant Virus-derived VP40 protein, expressed by E. coli , with tag free. The total length of VP40 Protein, Zaire ebolavirus is 296 a.a., .

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