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EcR

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Autophagy (1) Caspase (1) Endogenous Metabolite (1) Interleukin Related (1) Isotope-Labeled Compounds (1) Parasite (1)
By Research Areas:	Cancer (1) Cardiovascular Disease (2) Inflammation/Immunology (1)

Inhibitors & Agonists

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N2548

Turkesterone

Others Cardiovascular Disease

Turkesterone is a potent ecdysteroid. Turkesterone acts as an ecdysteroid receptor (EcR) agonist in some insect systems .

Turkesterone	Others	Cardiovascular Disease
Turkesterone is a potent ecdysteroid. Turkesterone acts as an ecdysteroid receptor (EcR) agonist in some insect systems .

HY-117386

Methoxyfenozide	Parasite	Others
Methoxyfenozide, a diacylhydrazine insecticide, selectively binds to lepidopteran ecdysone receptors (EcRs) over dipteran EcRs with K_d values of 0.5 and 124 nM, respectively. Methoxyfenozide is lethal to neonatal larvae of S. exigua, S. frugiperda, T. ni, O. nubilalis, L. pomonella, H. zea, and H. virescens (LC₅₀s=0.35, 0.2, 0.11, 0.18, 0.21, 0.79, and 3.12 mg/L, respectively).

HY-N6979

Crustecdysone 2 Publications Verification 20-Hydroxyecdysone	Caspase Autophagy Endogenous Metabolite	Cardiovascular Disease
Crustecdysone (20-Hydroxyecdysone) is a naturally occurring ecdysteroid hormone isolated from Serratula coronata which controls the ecdysis (moulting) and metamorphosis of arthropods, it inhibits caspase activity and induces autophagy via the 20E nuclear receptor complex, EcR-USP . Crustecdysone exhibits regulatory or protective roles in the cardiovascular system . Crustecdysone is an active metabolite of Ecdysone (HY-N0179) .

HY-16785

Veledimex INXN-1001; RG-115932	Interleukin Related	Inflammation/Immunology Cancer
Veledimex (INXN-1001), a synthetic analog of the insect molting hormone ecdysone, is an orally active activator ligand for a proprietary gene therapy promoter system. Veledimex can be used to activate certain genes using the ecdysone receptor (EcR)-based inducible gene regulation system, the RheoSwitch Therapeutic System (RTS). Veledimex can cross blood-brain barrier (BBB) in both orthotopic GL-261 mice and cynomolgus monkeys .

HY-117386S

Methoxyfenozide-d9	Isotope-Labeled Compounds	Others
Methoxyfenozide-d₉ is the deuterium labeled Methoxyfenozide[1]. Methoxyfenozide, a diacylhydrazine insecticide, selectively binds to lepidopteran ecdysone receptors (EcRs) over dipteran EcRs with Kd values of 0.5 and 124 nM, respectively. Methoxyfenozide is lethal to neonatal larvae of S. exigua, S. frugiperda, T. ni, O. nubilalis, L. pomonella, H. zea, and H. virescens (LC50s=0.35, 0.2, 0.11, 0.18, 0.21, 0.79, and 3.12 mg/L, respectively)[2].

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N2548

Turkesterone	Cardiovascular Disease other families Classification of Application Fields Source classification Plants Disease Research Fields Steroids	Others
Turkesterone is a potent ecdysteroid. Turkesterone acts as an ecdysteroid receptor (EcR) agonist in some insect systems .

HY-N6979

Crustecdysone 2 Publications Verification 20-Hydroxyecdysone	Cardiovascular Disease Structural Classification other families Classification of Application Fields Animals Source classification Plants Compositae Endogenous metabolite Disease Research Fields Canavalia gladiata (Jacq.) DC. Steroids	Caspase Autophagy Endogenous Metabolite
Crustecdysone (20-Hydroxyecdysone) is a naturally occurring ecdysteroid hormone isolated from Serratula coronata which controls the ecdysis (moulting) and metamorphosis of arthropods, it inhibits caspase activity and induces autophagy via the 20E nuclear receptor complex, EcR-USP . Crustecdysone exhibits regulatory or protective roles in the cardiovascular system . Crustecdysone is an active metabolite of Ecdysone (HY-N0179) .

Cat. No.	Product Name	Chemical Structure

HY-117386S

Methoxyfenozide-d9
Methoxyfenozide-d₉ is the deuterium labeled Methoxyfenozide[1]. Methoxyfenozide, a diacylhydrazine insecticide, selectively binds to lepidopteran ecdysone receptors (EcRs) over dipteran EcRs with Kd values of 0.5 and 124 nM, respectively. Methoxyfenozide is lethal to neonatal larvae of S. exigua, S. frugiperda, T. ni, O. nubilalis, L. pomonella, H. zea, and H. virescens (LC50s=0.35, 0.2, 0.11, 0.18, 0.21, 0.79, and 3.12 mg/L, respectively)[2].

Methoxyfenozide-d9

Methoxyfenozide-d₉ is the deuterium labeled Methoxyfenozide[1]. Methoxyfenozide, a diacylhydrazine insecticide, selectively binds to lepidopteran ecdysone receptors (EcRs) over dipteran EcRs with Kd values of 0.5 and 124 nM, respectively. Methoxyfenozide is lethal to neonatal larvae of S. exigua, S. frugiperda, T. ni, O. nubilalis, L. pomonella, H. zea, and H. virescens (LC50s=0.35, 0.2, 0.11, 0.18, 0.21, 0.79, and 3.12 mg/L, respectively)[2].

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EcR

Inhibitors & Agonists

NaturalProducts

Isotope-Labeled Compounds

Natural
Products