1. Immunology/Inflammation
    Metabolic Enzyme/Protease
  2. Interleukin Related
    Cytochrome P450
  3. Veledimex

Veledimex (Synonyms: INXN-1001; RG-115932)

Cat. No.: HY-16785 Purity: 99.19%
Handling Instructions

Veledimex is an oral activator ligand for a proprietary gene therapy promoter system, and a moderate inhibitor of and substrate for CYP3A4/5.

For research use only. We do not sell to patients.

Veledimex Chemical Structure

Veledimex Chemical Structure

CAS No. : 1093130-72-3

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 405 In-stock
Estimated Time of Arrival: December 31
1 mg USD 180 In-stock
Estimated Time of Arrival: December 31
5 mg USD 420 In-stock
Estimated Time of Arrival: December 31
10 mg USD 720 In-stock
Estimated Time of Arrival: December 31
25 mg USD 1440 In-stock
Estimated Time of Arrival: December 31
50 mg USD 2280 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Veledimex:

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

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  • Customer Review

Description

Veledimex is an oral activator ligand for a proprietary gene therapy promoter system, and a moderate inhibitor of and substrate for CYP3A4/5.

In Vivo

Veledimex generally has moderate to low oral bioavailability after a single oral administration in mice and monkeys (-56% in mice and up to 17.4% in cynomolgus monkeys) with mostly low plasma clearance (1399 and 1170 mL/h per kilogram in mice and monkeys, respectively), high volume of distribution (20271 and 9180 mL/h per kilogram in mice and monkeys, respectively), and long terminal half-lives (-10 hours in mice and -30 hours in monkeys) after intravenous administration[1]. Ad-RTS-mIL-12 + veledimex have demonstrated a dose-related increase in tumor IL-12 mRNA and IL-12 protein expression. Discontinuation of veledimex resulted in a return to baseline IL-12 mRNA and protein expression in numerous syngeneic mouse tumor models. Veledimex crosses the blood-brain-barrier in both naive and orthotopic GL-261 mice with increased brain tissue level of -6 fold observed in tumor bearing vs. normal mice. Ad-RTS-mIL-12 + veledimex demonstrate a dose-related increase in survival without significant adverse events[2].

Clinical Trial
Molecular Weight

438.60

Formula

C₂₇H₃₈N₂O₃

CAS No.

1093130-72-3

SMILES

O=C(NN(C(C1=CC(C)=CC(C)=C1)=O)[[email protected]@H](C(C)(C)C)CCC)C2=CC=CC(OC)=C2CC

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (57.00 mM; Need ultrasonic)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2800 mL 11.3999 mL 22.7998 mL
5 mM 0.4560 mL 2.2800 mL 4.5600 mL
10 mM 0.2280 mL 1.1400 mL 2.2800 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (5.70 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 99.19%

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Keywords:

VeledimexINXN-1001 RG-115932INXN1001INXN 1001RG115932RG 115932RG-115932Interleukin RelatedCytochrome P450ILCYPsInhibitorinhibitorinhibit

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Veledimex
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HY-16785
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