1. Immunology/Inflammation
    Metabolic Enzyme/Protease
  2. Interleukin Related
    Cytochrome P450
  3. Veledimex S enantiomer

Veledimex S enantiomer (Synonyms: INXN-1001 S enantiome; RG-115932 S enantiome)

Cat. No.: HY-16785B Purity: 99.52% ee.: 99.51%
Handling Instructions

Veledimex S enantiomer is the S enantiomer of veledimex. Veledimex is an oral activator ligand for a proprietary gene therapy promoter system, and a moderate inhibitor of and substrate for CYP3A4/5.

For research use only. We do not sell to patients.

Veledimex S enantiomer Chemical Structure

Veledimex S enantiomer Chemical Structure

CAS No. : 1093131-03-3

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 868 In-stock
Estimated Time of Arrival: December 31
1 mg USD 300 In-stock
Estimated Time of Arrival: December 31
5 mg USD 900 In-stock
Estimated Time of Arrival: December 31
10 mg USD 1320 In-stock
Estimated Time of Arrival: December 31
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Description

Veledimex S enantiomer is the S enantiomer of veledimex. Veledimex is an oral activator ligand for a proprietary gene therapy promoter system, and a moderate inhibitor of and substrate for CYP3A4/5.

In Vivo

Veledimex generally has moderate to low oral bioavailability after a single oral administration in mice and monkeys (∼56% in mice and up to 17.4% in cynomolgus monkeys) with mostly low plasma clearance (1399 and 1170 mL/h per kilogram in mice and monkeys, respectively), high volume of distribution (20271 and 9180 mL/h per kilogram in mice and monkeys, respectively), and long terminal half-lives (∼10 hours in mice and ∼30 hours in monkeys) after intravenous administration[1]. Ad-RTS-mIL-12 + veledimex have demonstrated a dose-related increase in tumor IL-12 mRNA and IL-12 protein expression. Discontinuation of veledimex resulted in a return to baseline IL-12 mRNA and protein expression in numerous syngeneic mouse tumor models. Veledimex crosses the blood-brain-barrier in both naive and orthotopic GL-261 mice with increased brain tissue level of ∼6 fold observed in tumor bearing vs. normal mice. Ad-RTS-mIL-12 + veledimex demonstrate a dose-related increase in survival without significant adverse events[2].

Molecular Weight

438.60

Formula

C₂₇H₃₈N₂O₃

CAS No.

1093131-03-3

SMILES

O=C(NN(C(C1=CC(C)=CC(C)=C1)=O)[[email protected]](C(C)(C)C)CCC)C2=CC=CC(OC)=C2CC

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
References

Purity: 99.52% ee.: 99.51%

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Veledimex S enantiomer
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