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Il12b

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  • HY-P700101AF
    Animal-Free IL-12 Protein, Human (HEK293, His)

    Interleukin 12; Interleukin-12 subunit alpha; Il-12A; Cytotoxic lymphocyte maturation factor 35 kDa subunit; CLMF p35; Il-12 subunit p35; Interleukin-12 subunit beta; Il-12b; Cytotoxic lymphocyte maturation factor 40 kDa subunit; CLMF p40; Il-12 subunit p40

    		 Human HEK293
    IL-35 Protein plays a pivotal role in immune regulation, forming the IL-12 cytokine with IL12B or the IL-35 cytokine with EBI3/IL27B. IL-12 regulates T-cell and natural killer-cell responses, inducing interferon-gamma production. IL-35 contributes significantly to maintaining immune homeostasis in the liver, acting as an immune-suppressive cytokine. Mechanistically, IL-12 exerts effects through the IL12R1 and IL12R2 receptor subunits, phosphorylating cellular substrates and regulating cytokine-responsive genes via phosphorylated STAT4. In the IL-35 context, unconventional receptors composed of IL12RB2 and gp130/IL6ST heterodimers or homodimers mediate signaling, requiring transcription factors STAT1 and STAT4. IL-35 interacts with NBR1, promoting IL-12 secretion, and the IL-35 heterodimer with EBI3/IL27B is non-disulfide-linked, distinguishing it from IL-12. Animal-Free IL-12 Protein, Human (HEK293, His) is a recombinant protein dimer complex containing human-derived animal-FreeIL-12 protein, expressed by HEK293, with C-His labeled tag. Animal-Free IL-12 Protein, Human (HEK293, His), has molecular weight of ~59.55 kDa.
  • HY-P73156
    GMP IL-12 Protein, Human (HEK293, His)

    GMP Il-12; Interleukin 12; Interleukin-12 subunit alpha; Il-12A; Cytotoxic lymphocyte maturation factor 35 kDa subunit; CLMF p35; Il-12 subunit p35; Interleukin-12 subunit beta; Il-12b; Cytotoxic lymphocyte maturation factor 40 kDa subunit; CLMF p40; Il-12 subunit p40

    		 Human HEK293
    Interleukin-12 subunit alpha (IL-12A; IL-12p35), an immune-suppressive cytokine, encodes a subunit of the cytokine IL-12 that acts on T and natural killer cells, and has a broad array of biological activities. IL-12A heterodimerizes with IL-12B to form the IL-12 cytokine or with EBI3/IL27B to form the IL-35 cytokine. IL-12 Protein, Human (HEK293, His), a recombinant GMP-grade protein,  is produced in HEK293 cells with a C-Terminal His-tag . It consists of IL-12A (M1-S219) and IL-12B (M1-S328).
  • HY-P7032G
    GMP IL-12 Protein, Human (HEK293)

    Il-12; Interleukin 12; Interleukin-12 subunit alpha; Il-12A; Cytotoxic lymphocyte maturation factor 35 kDa subunit; CLMF p35; Il-12 subunit p35; Interleukin-12 subunit beta; Il-12b; Cytotoxic lymphocyte maturation factor 40 kDa subunit; CLMF p40; Il-12 subunit p40

    		 Human HEK293
    Interleukin-12 subunit alpha (IL-12A; IL-12p35), an immune-suppressive cytokine, encodes a subunit of the cytokine IL-12 that acts on T and natural killer cells, and has a broad array of biological activities. IL-12A heterodimerizes with IL-12B to form the IL-12 cytokine or with EBI3/IL27B to form the IL-35 cytokine. GMP IL-12 Protein, Human (HEK293), a recombinant GMP-grade protein,  is produced in HEK293 cells. It consists of IL-12A and IL-12B.
  • HY-P7032
    IL-12 Protein, Human (HEK293)

    Il-12; Interleukin 12; Interleukin-12 subunit alpha; Il-12A; Cytotoxic lymphocyte maturation factor 35 kDa subunit; CLMF p35; Il-12 subunit p35; Interleukin-12 subunit beta; Il-12b; Cytotoxic lymphocyte maturation factor 40 kDa subunit; CLMF p40; Il-12 subunit p40

    		 Human HEK293
    IL-12 Protein, Human (HEK293) is a HEK293 cell derived heterodimeric, pro-inflammatory cytokine.
  • HY-P77702
    IL-12 Protein, Human (Biotinylated, HEK293, His-Avi)

    CLMF; CLMF2; Il-12A; Il-12b; Il12; Il12 p70; IMD28; IMD29; NFSK; NKSF1; NKSF2; P35; Il-12 subunit p35; Il12A; interleukin 12

    		 Human HEK293
    IL-35 Protein plays a pivotal role in immune regulation, forming the IL-12 cytokine with IL12B or the IL-35 cytokine with EBI3/IL27B. IL-12 regulates T-cell and natural killer-cell responses, inducing interferon-gamma production. IL-35 contributes significantly to maintaining immune homeostasis in the liver, acting as an immune-suppressive cytokine. Mechanistically, IL-12 exerts effects through the IL12R1 and IL12R2 receptor subunits, phosphorylating cellular substrates and regulating cytokine-responsive genes via phosphorylated STAT4. In the IL-35 context, unconventional receptors composed of IL12RB2 and gp130/IL6ST heterodimers or homodimers mediate signaling, requiring transcription factors STAT1 and STAT4. IL-35 interacts with NBR1, promoting IL-12 secretion, and the IL-35 heterodimer with EBI3/IL27B is non-disulfide-linked, distinguishing it from IL-12. IL-12 Protein, Human (Biotinylated, HEK293, His-Avi) is a recombinant protein dimer complex containing human-derived IL-12 protein, expressed by HEK293, with C-Avi, C-His labeled tag. IL-12 Protein, Human (Biotinylated, HEK293, His-Avi), has molecular weight of ~40-45 kDa.
  • HY-P77511
    IL-12 Protein, Human (Biotinylated, HEK293, His)

    Il-12; Interleukin 12; Interleukin-12 subunit alpha; Il-12A; Cytotoxic lymphocyte maturation factor 35 kDa subunit; CLMF p35; Il-12 subunit p35; Interleukin-12 subunit beta; Il-12b; Cytotoxic lymphocyte maturation factor 40 kDa subunit; CLMF p40; Il-12 subunit p40

    		 Human HEK293
    IL-12 beta Protein, also known as natural killer cell stimulatory factor 2, is a common subunit (p40) of IL-12 and IL-23. IL-12 is a inflammatory factor expressed by activated macrophages, and involves in Th1-type immune response against cancer. IL-12 beta Protein located outside the cell membrane, involves in singalling mediated by Jak-STAT. IL-12 beta Protein consists of 328 amino acids (M1-S328) with a fibronectin type-III domain (237-328 a.a). IL-12 beta Protein, Human (M1-S219) is a biotinylated protein, produced in HEK293 cells with a C-Terminal His-tag.
  • HY-P700100AF
    Animal-Free IL-12 beta Protein, Human (His)

    Interleukin-12 subunit beta; Il-12b; Cytotoxic lymphocyte maturation factor 40 kDa subunit; CLMF p40; Il-12 subunit p40; NK cell stimulatory factor chain 2; NKSF2; Il12b; NKSF2

    		 Human E. coli
    IL-12 beta protein is a multifunctional cytokine that serves as a growth factor for activated T cells and NK cells, amplifies the lytic activity of NK/lymphokine-activated killer cells, and induces IFN production by resting peripheral blood mononuclear cells -γ. peripheral blood mononuclear cells). Animal-Free IL-12 beta Protein, Human (His) is the recombinant human-derived animal-FreeIL-12 beta protein, expressed by E. coli , with His labeled tag. The total length of Animal-Free IL-12 beta Protein, Human (His) is 306 a.a., with molecular weight of ~35.64 kDa.
  • HY-P70617
    IL-12 beta Protein, Human (HEK293)

    Interleukin-12 subunit beta; Il-12b; Cytotoxic lymphocyte maturation factor 40 kDa subunit; CLMF p40; Il-12 subunit p40; NK cell stimulatory factor chain 2; NKSF2; Il12b; NKSF2

    		 Human HEK293
    IL-12 beta Protein, also known as natural killer cell stimulatory factor 2, is a common subunit (p40) of IL-12 and IL-23. IL-12 is a inflammatory factor expressed by activated macrophages, and involves in Th1-type immune response against cancer. IL-12 beta Protein located outside the cell membrane, involves in singalling mediated by Jak-STAT. IL-12 beta Protein consists of 328 amino acids (M1-S328) with a fibronectin type-III domain (237-328 a.a). IL-12 beta Protein, Human (I23-S328) is produced in HEK293 cells with tag free.
  • HY-P73160
    IL-12 beta Protein, Human (HEK293, Fc)

    Il-12; Interleukin 12; Interleukin-12 subunit alpha; Il-12A; Cytotoxic lymphocyte maturation factor 35 kDa subunit; CLMF p35; Il-12 subunit p35; Interleukin-12 subunit beta; Il-12b; Cytotoxic lymphocyte maturation factor 40 kDa subunit; CLMF p40; Il-12 subunit p40

    		 Human HEK293
    IL-12 beta Protein, also known as natural killer cell stimulatory factor 2, is a common subunit (p40) of IL-12 and IL-23. IL-12 is a inflammatory factor expressed by activated macrophages, and involves in Th1-type immune response against cancer. IL-12 beta Protein located outside the cell membrane, involves in singalling mediated by Jak-STAT. IL-12 beta Protein consists of 328 amino acids (M1-S328) with a fibronectin type-III domain (237-328 a.a). IL-12 beta Protein, Human (M1-S328) is produced in HEK293 cells with a C-Terminal Fc-tag.
  • HY-P700745
    IL-23 alpha (170a.a) & IL-12 beta (306a.a) Heterodimer Protein, Human (Biotinylated, HEK293, His-Avi)

    Il23 alpha; Il12 beta; Il23 alpha&Il12 beta ; Il12 β; Il23 alpha&Il12 β; Il-23A&Il-12b; Il23A&Il12b

    		 Human HEK293
    IL-23, collaborating with IL12B, constitutes the pro-inflammatory cytokine IL-23, crucial in innate and adaptive immunity. Released by antigen-presenting cells like dendritic cells or macrophages, IL-23 binds to IL12RB1 and IL23R, activating JAK2 and TYK2. This cascade phosphorylates STAT3 and STAT4, activating pathways like p38 MAPK or NF-kappa-B, inducing pro-inflammatory cytokines. IL-23 contributes to intracellular bacterial clearance and supports the expansion of T-helper 17 cells, including IL-17 producers. The disulfide-linked IL-23 interacts with IL12B and IL23R, recruiting IL12RB1. IL-23 alpha (170a.a) & IL-12 beta (306a.a) Heterodimer Protein, Human (Biotinylated, HEK293, His-Avi) is a recombinant protein dimer complex containing human-derived IL-23 alpha, expressed by HEK293, with C-Avi, C-His labeled tag. IL-23 alpha (170a.a) & IL-12 beta (306a.a) Heterodimer Protein, Human (Biotinylated, HEK293, His-Avi), has molecular weight of 24 kDa (IL-23 alpha) & 40-50 kDa (IL-12 beta), respectively.
  • HY-P72771
    Human IL-23A & Mouse IL-12B Heterodimer Protein (HEK293, His)

    SGRF; Il-23p19; CLMF p40; Il-12 subunit p40; NKSF2

    		 Mouse;Human HEK293
    IL-23, collaborating with IL12B, constitutes the pro-inflammatory cytokine IL-23, crucial in innate and adaptive immunity. Released by antigen-presenting cells like dendritic cells or macrophages, IL-23 binds to IL12RB1 and IL23R, activating JAK2 and TYK2. This cascade phosphorylates STAT3 and STAT4, activating pathways like p38 MAPK or NF-kappa-B, inducing pro-inflammatory cytokines. IL-23 contributes to intracellular bacterial clearance and supports the expansion of T-helper 17 cells, including IL-17 producers. The disulfide-linked IL-23 interacts with IL12B and IL23R, recruiting IL12RB1. Human IL-23A & Mouse IL-12B Heterodimer Protein (HEK293, His) is a recombinant protein dimer complex containing mouse, human-derived Human IL-23A & Mouse IL-12B Heterodimer protein, expressed by HEK293, with C-6*His labeled tag. Human IL-23A & Mouse IL-12B Heterodimer Protein (HEK293, His), has molecular weight of 65-80 kDa.

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