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LHF-418

" in MedChemExpress (MCE) Product Catalog:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-161450
    LHF418

    		PROTACs Ras Cancer
    LHF418 is an effective SOS1 PROTAC degrader with a DC50 value of 209.4 nM in A549 cells. LHF418 can effectively inhibit RAS signaling and colony formation in KRAS-driven cancer cells. (Structural note: (Blue: Cereblon ligand (HY-A0003), Black: linker; Pink: SOS1 binder SOS1 Ligand intermediate-3 (HY-161452)) .
    <em>LHF418</em>
  • HY-161451
    Lenalidomide nonanedioic acid

    		E3 Ligase Ligand-Linker Conjugates Cancer
    Lenalidomide nonanedioic acid is a conjugate of the E3 ligase ligand and linker of LHF418 (HY-161450). Lenalidomide nonanedioic acid can be used as a key intermediate for the synthesis of intact PROTACs molecules .
    Lenalidomide nonanedioic acid

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