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Results for "

MDM4

" in MedChemExpress (MCE) Product Catalog:

8

Inhibitors & Agonists

1

Recombinant Proteins

Cat. No. Compare Product Name Species Source
  • HY-P74756
    MDM4/MDMX Protein, Human (His)

    Protein MDM4; Protein MDMx; MDM4; MDMX

    		 Human E. coli
    MDM4/MDMX Protein collaborates with MDM2 to regulate TP53 (p53), inhibiting the transcriptional activation domains of p53 and p73. This impedes their ability to induce cell cycle arrest and apoptosis. MDM4 hinders MDM2 degradation, reverses MDM2-mediated TP53 degradation, and suppresses TP53 transactivation and apoptosis. Forming a trimeric complex with MDM2 and USP2, MDM4 interacts with TP53, TP73, and USP2. When phosphorylated, it interacts with YWHAG, negatively regulating its activity towards TP53. These interactions underscore MDM4's intricate role in finely tuning the TP53 pathway, regulating cellular responses to stress and DNA damage. MDM4/MDMX Protein, Human (His) is the recombinant human-derived MDM4/MDMX protein, expressed by E. coli, with N-His labeled tag. The total length of MDM4/MDMX Protein, Human (His) is 134 a.a., with molecular weight of ~19.4 kDa.

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