Search Result

Results for "

RRM2

" in MedChemExpress (MCE) Product Catalog:

By Targets:	CDK (1) HBV (1) Small Interfering RNA (siRNA) (2)
By Research Areas:	Cancer (2) Infection (1) Neurological Disease (2)

Inhibitors & Agonists

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

GW8510	CDK	Neurological Disease Cancer
GW8510 is a potent cyclin-dependent kinase-2 (CDK2) inhibitor. GW8510 is also a ribonucleotide reductase M2 (RRM2) inhibitor. GW8510 exhibits neuroprotective and anticancer activities ^[2] .

Osalmid Oxaphenamide; 4'-Hydroxysalicylanilide	HBV	Infection
Osalmid is a ribonucleotide reductase small subunit M2 (RRM2) targeting compound; suppresses ribonucleotide reductase activity with an IC₅₀ of 8.23 μM.

RRM2 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
RRM2 Human Pre-designed siRNA Set A contains three designed siRNAs for RRM2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

RRM2 Human Pre-designed siRNA Set A RRM2 Human Pre-designed siRNA Set A

RRM2B Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
RRM2B Human Pre-designed siRNA Set A contains three designed siRNAs for RRM2B gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

RRM2B Human Pre-designed siRNA Set A RRM2B Human Pre-designed siRNA Set A

NSC 194308	Others	Cancer
NSC 194308, a *U2AF2-RNA* complexes enhancer, increases association of the U2AF1-U2AF2-SF1-splice site RNA complex by binding a site between the U2AF2 RNA recognition motifs (RRM1 and RRM2). NSC 194308 inhibits pre-mRNA splicing by stalling spliceosome assembly at the point where U2AF helps recruit U2 snRNP to the branchpoint. NSC 194308 enhances the binding of pre-mRNA to U2AF2, selectively triggering cell death in leukemia cell lines containing spliceosome mutations .

rTRD01	Others	Neurological Disease
rTRD01 is a TDP-43 ligand that binds to TDP-43’s RRM1 and RRM2 domains (K_d=89 uM for TDP-43_102–269). rTRD01 partially disrupts TDP-43’s interaction with the hexanucleotide RNA repeat of the disease-linked c9orf72 gene. rTRD01 can be used for the research of neurodegenerative diseases .

Cat. No.	Compare	Product Name	Species	Source

	RRM2 Protein, Human (HEK293, His) Ribonucleoside-Diphosphate Reductase Subunit M2; Ribonucleotide Reductase Small Chain; Ribonucleotide Reductase Small Subunit; RRM2; RR2	Human	HEK293
	RRM2 Protein, pivotal in DNA synthesis, catalyzes deoxyribonucleotide biosynthesis from ribonucleotide precursors, ensuring vital building blocks for DNA replication. Beyond nucleotide biosynthesis, RRM2 inhibits Wnt signaling, indicating involvement in regulating this crucial cellular pathway. RRM2 Protein, Human (HEK293, His) is the recombinant human-derived RRM2 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of RRM2 Protein, Human (HEK293, His) is 389 a.a., with molecular weight of ~47.0 kDa.

	p53R2 Protein, Human (His) Ribonucleoside-diphosphate reductase subunit M2 B; p53R2; RRM2B	Human	E. coli
	The p53R2 protein is essential for cell survival and operates in a p53/TP53-dependent manner to support DNA repair. It provides essential deoxyribonucleotides for DNA repair, particularly in G1 or G2 arrested cells, and contains an iron-tyrosyl radical center critical for catalysis. p53R2 Protein, Human (His) is the recombinant human-derived p53R2 protein, expressed by E. coli , with N-His labeled tag. The total length of p53R2 Protein, Human (His) is 351 a.a., with molecular weight of ~43 kDa.


Products	In-stock - + Add to Cart
Cat. No.
Species
Source
Tag
Accession
Gene ID
Molecular Weight
Purity
Endotoxin Level
Biological Activity
Appearance
Formulation
Storage & Stability
Shipping
Free Sample	Yes No
Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

Inquiry Online

Your information is safe with us. * Required Fields.

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社
Salutation			Country or Region *
Applicant Name *			Organization Name *
Department *
Email Address *			Product Name *
Cat. No.			Requested quantity *
Phone Number *
Remarks

Inquiry Online

Inquiry Information

Name
Email *

	Sorry, but the email address you supplied was invalid.