NSC 194308
Based on 1 Customer Validation
NSC 194308, a U2AF2-RNA complexes enhancer, increases association of the U2AF1-U2AF2-SF1-splice site RNA complex by binding a site between the U2AF2 RNA recognition motifs (RRM1 and RRM2). NSC 194308 inhibits pre-mRNA splicing by stalling spliceosome assembly at the point where U2AF helps recruit U2 snRNP to the branchpoint. NSC 194308 enhances the binding of pre-mRNA to U2AF2, selectively triggering cell death in leukemia cell lines containing spliceosome mutations.
For research use only. We do not sell to patients.
- Purity: 99.86%
- CAS No.: 90379-42-3
- Formula: C12H22N2O3S2
- Molecular Weight:306.44
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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All DNA/RNA Synthesis Isoforms
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Biological Activity
Chemical Information
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CAS No. 90379-42-3
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Appearance Solid
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Molecular Weight 306.44
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Formula C12H22N2O3S2
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Color White to off-white
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SMILES
N=C(CS[S](=O)(O)=O)NC[C@@H]1C(CC2CC1)C2(C)C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : ≥ 50 mg/mL (163.16 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (272 KB)
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SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Portuguese - PT (254 KB)
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Handling Instructions (2659 KB)
References
[1]. Rakesh Chatrikhi, et al. A synthetic small molecule stalls pre-mRNA splicing by promoting an early-stage U2AF2-RNA complex. Cell Chem Biol. 2021 Aug 19;28(8):1145-1157.e6. [Content Brief]
[2]. Riccardo Rozza, et al. Assessing the Binding Mode of a Splicing Modulator Stimulating Pre-mRNA Binding to the Plastic U2AF2 Splicing Factor. J Chem Inf Model. 2023 Dec 11;63(23):7508-7517. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.2633 mL | 16.3164 mL | 32.6328 mL | 81.5820 mL |
| 5 mM | 0.6527 mL | 3.2633 mL | 6.5266 mL | 16.3164 mL | |
| 10 mM | 0.3263 mL | 1.6316 mL | 3.2633 mL | 8.1582 mL | |
| 15 mM | 0.2176 mL | 1.0878 mL | 2.1755 mL | 5.4388 mL | |
| 20 mM | 0.1632 mL | 0.8158 mL | 1.6316 mL | 4.0791 mL | |
| 25 mM | 0.1305 mL | 0.6527 mL | 1.3053 mL | 3.2633 mL | |
| 30 mM | 0.1088 mL | 0.5439 mL | 1.0878 mL | 2.7194 mL | |
| 40 mM | 0.0816 mL | 0.4079 mL | 0.8158 mL | 2.0396 mL | |
| 50 mM | 0.0653 mL | 0.3263 mL | 0.6527 mL | 1.6316 mL | |
| 60 mM | 0.0544 mL | 0.2719 mL | 0.5439 mL | 1.3597 mL | |
| 80 mM | 0.0408 mL | 0.2040 mL | 0.4079 mL | 1.0198 mL | |
| 100 mM | 0.0326 mL | 0.1632 mL | 0.3263 mL | 0.8158 mL |
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