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NSC 194308, a U2AF2-RNA complexes enhancer, increases association of the U2AF1-U2AF2-SF1-splice site RNA complex by binding a site between the U2AF2 RNA recognition motifs (RRM1 and RRM2). NSC 194308 inhibits pre-mRNA splicing by stalling spliceosome assembly at the point where U2AF helps recruit U2 snRNP to the branchpoint. NSC 194308 enhances the binding of pre-mRNA to U2AF2, selectively triggering cell death in leukemia cell lines containing spliceosome mutations.

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NSC 194308 Chemical Structure

NSC 194308 Chemical Structure

CAS No. : 90379-42-3

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Description

NSC 194308, a U2AF2-RNA complexes enhancer, increases association of the U2AF1-U2AF2-SF1-splice site RNA complex by binding a site between the U2AF2 RNA recognition motifs (RRM1 and RRM2). NSC 194308 inhibits pre-mRNA splicing by stalling spliceosome assembly at the point where U2AF helps recruit U2 snRNP to the branchpoint. NSC 194308 enhances the binding of pre-mRNA to U2AF2, selectively triggering cell death in leukemia cell lines containing spliceosome mutations[1].

Molecular Weight

306.44

Formula

C12H22N2O3S2
CAS No.
SMILES

N=C(CS[S](=O)(O)=O)NC[C@@H]1C(CC2CC1)C2(C)C
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NSC 194308 Related Classifications

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Keywords:

NSC 19430890379-42-3NSC194308NSC-194308OthersU2AF2-RNAU2AF1-U2AF2-SF1-spliceRRM1RRM2pre-mRNAU2AFU2 snRNPleukemia cellspliceosome mutationsInhibitorinhibitorinhibit

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