90379-42-3
Chemical Structure
NSC 194308
- CAS No.: 90379-42-3
- Formula:C12H22N2O3S2
- Molecular Weight:306.44
InChIKey: VOOABHIKMGRJFC-XNWIYYODSA-N
SMILES: N=C(CS[S](=O)(O)=O)NC[C@@H]1C(CC2CC1)C2(C)C
Biological Activity: NSC 194308, a U2AF2-RNA complexes enhancer, increases association of the U2AF1-U2AF2-SF1-splice site RNA complex by binding a site between the U2AF2 RNA recognition motifs (RRM1 and RRM2). NSC 194308 inhibits pre-mRNA splicing by stalling spliceosome assembly at the point where U2AF helps recruit U2 snRNP to the branchpoint. NSC 194308 enhances the binding of pre-mRNA to U2AF2, selectively triggering cell death in leukemia cell lines containing spliceosome mutations[1].
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NSC 194308 | 99.86% | NSC 194308, a U2AF2-RNA complexes enhancer, increases association of the U2AF1-U2AF2-SF1-splice site RNA complex by binding a site between the U2AF2 RNA recognition motifs (RRM1 and RRM2). NSC 194308 inhibits pre-mRNA splicing by stalling spliceosome assembly at the point where U2AF helps recruit U2 snRNP to the branchpoint. NSC 194308 enhances the binding of pre-mRNA to U2AF2, selectively triggering cell death in leukemia cell lines containing spliceosome mutations. | ||||||||||||||||||||
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Keywords
