p53R2 Protein, Human (His)

The p53R2 protein is essential for cell survival and operates in a p53/TP53-dependent manner to support DNA repair. It provides essential deoxyribonucleotides for DNA repair, particularly in G1 or G2 arrested cells, and contains an iron-tyrosyl radical center critical for catalysis. p53R2 Protein, Human (His) is the recombinant human-derived p53R2 protein, expressed by E. coli , with N-His labeled tag. The total length of p53R2 Protein, Human (His) is 351 a.a., with molecular weight of ~43 kDa.

p53R2, a crucial player in cellular survival, operates in a p53/TP53-dependent manner to facilitate the repair of damaged DNA. It assumes a vital role by providing deoxyribonucleotides essential for DNA repair processes, particularly in cells arrested at G1 or G2 phases. The protein harbors an iron-tyrosyl free radical center, indispensable for its catalytic function. Notably, p53R2 forms an active ribonucleotide reductase (RNR) complex in conjunction with RRM1. This complex is expressed in both resting and proliferating cells, responding adeptly to DNA damage, highlighting its significance in maintaining genomic integrity.

Human

E. coli

N-His

Q7LG56 (M1-F351)

50484  [NCBI]

Approximately 43 kDa

Greater than 90% as determined by reducing SDS-PAGE

<1 EU/μg, determined by LAL method.