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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
2 Results for "
SIAIS056
" in MedChemExpress (MCE) Product Catalog:
Products (2)
2 Results for "SIAIS056" in MCE Product Catalog:
Cat. No.: HY-180969
CAS No.: 2378581-37-2
SIAIS056 is a BCR-ABL PROTAC degrader with a DC50 value of 0.18 nM. SIAIS056 time-dependently inhibits the BCR-ABL signaling pathway, accompanied by decreased phosphorylation of BCR-ABL and the downstream molecules STAT5 and CRKL in K562 cells. SIAIS056 induces the degradation of several clinically relevant resistance-conferring mutations of BCR-ABL. SIAIS056 exhibits anti-proliferative activity and induces substantial tumor regression in K562 xenograft models. SIAIS056 can be used for leukemia research .
Cat. No.: HY-W586107
CAS No.: 2378582-97-7
Target:
Research Areas:
Thalidomide-SH is an E3 ubiquitin ligase cereblon (CRBN) ligand that recruits cereblon protein. Thalidomide-SH is a Thalidomide (HY-14658) derivative. Thalidomide-SH can be linked to a target protein ligand via a linker to form a PROTAC, such as SIAIS056 (HY-180969) .
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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
