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SIAIS056

" in MedChemExpress (MCE) Product Catalog:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-180969
    SIAIS056

    		PROTACs Bcr-Abl Cancer
    SIAIS056 is a BCR-ABL PROTAC degrader with a DC50 value of 0.18 nM. SIAIS056 time-dependently inhibits the BCR-ABL signaling pathway, accompanied by decreased phosphorylation of BCR-ABL and the downstream molecules STAT5 and CRKL in K562 cells. SIAIS056 induces the degradation of several clinically relevant resistance-conferring mutations of BCR-ABL. SIAIS056 exhibits anti-proliferative activity and induces substantial tumor regression in K562 xenograft models. SIAIS056 can be used for leukemia research .
    SIAIS056
  • HY-W586107
    Thalidomide-SH

    		Ligands for E3 Ligase Others
    Thalidomide-SH is an E3 ubiquitin ligase cereblon (CRBN) ligand that recruits cereblon protein. Thalidomide-SH is a Thalidomide (HY-14658) derivative. Thalidomide-SH can be linked to a target protein ligand via a linker to form a PROTAC, such as SIAIS056 (HY-180969) .
    Thalidomide-SH

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