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TNFSF9

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  • HY-P700160AF
    Animal-Free 4-1BBL/TNFSF9 Protein, Mouse (His)

    41BB Ligand; 4-1BB Ligand; 4-1BBL; CD137L; TNFSF9

    		 Mouse E. coli
    4-1BBL/TNFSF9 Protein, a cytokine, binds TNFRSF9, inducing proliferation in activated peripheral blood T-cells. It's implicated in activation-induced cell death (AICD) and contributes to cognate interactions between T-cells and B-cells/macrophages. Functioning as a homotrimer enhances its biological activity. Animal-Free 4-1BBL/TNFSF9 Protein, Mouse (His) is the recombinant mouse-derived animal-Free4-1BBL/TNFSF9 protein, expressed by E. coli , with C-His labeled tag. The total length of Animal-Free 4-1BBL/TNFSF9 Protein, Mouse (His) is 108 a.a., with molecular weight of ~23.91 kDa.
  • HY-P7446
    4-1BBL/TNFSF9 Protein, Mouse (HEK293, His)

    rMu4-1BB Ligand/TNFSF9, His; 4-1BBL; CD137L; 4-1BB Ligand; TNFSF9

    		 Mouse HEK293
    4-1BBL (4-1BB ligand) is a type II membrane protein of the TNF superfamily, is expressed on antigen-presenting cells. 4-1BB with 4-1BBL can induce T-cell expansion, cytokine induction, differentiation, and upregulation of anti-apoptotic genes as well as protect T cells from activation-induced cell death (AICD). 4-1BBL stimulates T cell proliferation and induces effective anti-tumor immune responses. 4-1BBL is an immunostimulant molecule that interacts with the 4-1BB high-affinity receptor during the antigen presentation, providing costimulatory signals to both CD4+ and CD8+ T cells through the activation of NF-kB, c-Jun, and p38 downstream pathways, triggering pleiotropic effects on the immune system. 4-1BBL/TNFSF9 Protein, Mouse (HEK293, His) is a recombinant protein with a N-Terminal His label, It consists of 206 amino acids (R104-E309) and is produced in HEK293 cells.
  • HY-P7447
    4-1BB/TNFRSF9 Protein, Mouse (HEK293, Fc, solution)

    rMu4-1BB/TNFRSF9, C-Fc; CD137; 4-1 BB; TNFRSF-9

    		 Mouse HEK293
    4-1BB (CD137; TNFRSF9), a receptor of TNFSF9/4-1BBL, belongs to the tumor necrosis factor (TNF) receptor superfamily. 4-1BB is helpful for T cell activation and development, and also induces peripheral mononuclear cell proliferation and migration to the tumor microenvironment. 4-1BB is also involved in enhancing Nrf2 and NF-κB pathway mediated apoptosis of endothelial cells. Mouse 4-1BB protein is a surface glycoprotein with a transmembrane domain (188-208 a.a.). 4-1BB/TNFRSF9 Protein, Mouse (HEK293, Fc, solution) is the extracellular part (V24-L187) of 4-1BB protein, produced by HEK293 cells with C-terminal Fc-tag.

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