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cytochrome P450 17α

" in MedChemExpress (MCE) Product Catalog:

標的別:	Cytochrome P450 (4) Reference Standards (1)
研究分野別:	Cancer (4)

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Targets Recommended: Cytochrome P450

製品番号	製品名	Target	研究分野	構造式

HY-70013

Abiraterone 20+ Cited Publications CB-7598	Cytochrome P450	Cancer
Abiraterone is a potent and irreversible *CYP17A1* inhibitor with antiandrogen activity, which inhibits both the 17α-hydroxylase and 17,20-lyase activity of the cytochrome p450 enzyme CYP17 with IC₅₀s of 2.5 nM and 15 nM, respectively.

HY-70013S

Abiraterone-d4 CB-7598-d₄	Cytochrome P450	Cancer
Abiraterone-d₄ is the deuterium labeled Abiraterone. Abiraterone is a potent and irreversible CYP17A1 inhibitor with antiandrogen activity, which inhibits both the 17α-hydroxylase and 17,20-lyase activity of the cytochrome p450 enzyme CYP17 with IC50s of 2.5 nM and 15 nM, respectively.

HY-148430

4-Pyridylmethyl adamantanecarboxamide	Cytochrome P450	Cancer
4-Pyridylmethyl adamantanecarboxamide (Compound 11) is an Aromatase inhibitor with an IC₅₀ of 1.5 μM against hAromatase. 4-Pyridylmethyl adamantanecarboxamide inhibits the C17,20-lyase activity of testicular cytochrome P450_17α with an IC₅₀ of 1600 nM, and also inhibits the 17α-hydroxylase activity of this enzyme with an IC₅₀ of 7700 nM. 4-Pyridylmethyl adamantanecarboxamide can be used in the research of prostate cancer .

HY-70013R

Abiraterone (Standard) CB-7598 (Standard)	Reference Standards Cytochrome P450	Cancer
Abiraterone (Standard) is the analytical standard of Abiraterone. This product is intended for research and analytical applications. Abiraterone is a potent and irreversible *CYP17A1* inhibitor with antiandrogen activity, which inhibits both the 17α-hydroxylase and 17,20-lyase activity of the cytochrome p450 enzyme CYP17 with IC₅₀s of 2.5 nM and 15 nM, respectively.

製品番号	製品名	構造式

HY-70013S

Abiraterone-d4
Abiraterone-d₄ is the deuterium labeled Abiraterone. Abiraterone is a potent and irreversible CYP17A1 inhibitor with antiandrogen activity, which inhibits both the 17α-hydroxylase and 17,20-lyase activity of the cytochrome p450 enzyme CYP17 with IC50s of 2.5 nM and 15 nM, respectively.

製品番号	Compare	製品名	Application	Reactivity	Image

HY-P85566

	Cytochrome P450 17A1 Antibody (YA5258) 20 lyase; CP17A_HUMAN; CPT7; CYP17; CYP17A1; CYPXVII; cytochrome P450 17A1; cytochrome P450 family 17; cytochrome P450 family 17 subfamily A polypeptide 1; cytochrome P450 subfamily XVII; steroid 17 alpha hydroxylase; adrenal hyperplasia; cytochrome P450 XVIIA1; cytochrome P450-C17; cytochrome P450c17; OTTHUMP00000020382; P450 C17; P450c17; S17AH; Steroid 17 alpha hydroxylase/17,20 lyase; Steroid 17 alpha monooxygenase; Steroid 17-alpha-hydroxylase/17; Steroid 17-alpha-monooxygenase.	WB	Human
	Cytochrome P450 17A1 Antibody (YA5258) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to Cytochrome P450 17A1.

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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