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pivaloyloxymethyl ester prodrugs

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Drug Intermediate (1)

Targets Recommended: CETP Carboxylesterase (CES) Hormone-Sensitive Lipase (HSL)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-Y0643

Pivaloyloxymethyl chloride	Drug Intermediate	Others
Pivaloyloxymethyl chloride is an organic intermediate used to introduce the pivaloyloxymethyl (POM) protecting group, and it can be prepared from trimethylacetic acid and chloromethyl chlorosulfonate as raw materials. Pivaloyloxymethyl chloride is an alkylating reagent for the synthesis of phosphonic acid prodrugs; the introduction of the hydrophobic POM group enhances the lipid solubility and membrane permeability of molecules. Pivaloyloxymethyl chloride can be used in the synthesis of tetrakis (pivaloyloxymethyl) methylenebisphosphonate, which is a precursor of the pivaloyloxymethyl clodronate prodrug. Pivaloyloxymethyl chloridecan support the synthesis of aryl/pivaloyloxymethyl mixed phosphonate prodrugs of butyrophilin 3A1 ligands .

Cat. No.	Product Name	Type

HY-Y0643

Pivaloyloxymethyl chloride	Biochemical Assay Reagents
Pivaloyloxymethyl chloride is an organic intermediate used to introduce the pivaloyloxymethyl (POM) protecting group, and it can be prepared from trimethylacetic acid and chloromethyl chlorosulfonate as raw materials. Pivaloyloxymethyl chloride is an alkylating reagent for the synthesis of phosphonic acid prodrugs; the introduction of the hydrophobic POM group enhances the lipid solubility and membrane permeability of molecules. Pivaloyloxymethyl chloride can be used in the synthesis of tetrakis (pivaloyloxymethyl) methylenebisphosphonate, which is a precursor of the pivaloyloxymethyl clodronate prodrug. Pivaloyloxymethyl chloridecan support the synthesis of aryl/pivaloyloxymethyl mixed phosphonate prodrugs of butyrophilin 3A1 ligands .

Pivaloyloxymethyl chloride

Biochemical Assay Reagents

Pivaloyloxymethyl chloride is an organic intermediate used to introduce the pivaloyloxymethyl (POM) protecting group, and it can be prepared from trimethylacetic acid and chloromethyl chlorosulfonate as raw materials. Pivaloyloxymethyl chloride is an alkylating reagent for the synthesis of phosphonic acid prodrugs; the introduction of the hydrophobic POM group enhances the lipid solubility and membrane permeability of molecules. Pivaloyloxymethyl chloride can be used in the synthesis of tetrakis (pivaloyloxymethyl) methylenebisphosphonate, which is a precursor of the pivaloyloxymethyl clodronate prodrug. Pivaloyloxymethyl chloridecan support the synthesis of aryl/pivaloyloxymethyl mixed phosphonate prodrugs of butyrophilin 3A1 ligands .

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