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  4. Solutol HS-15

Solutol HS-15  (Synonyms: Polyethylene glycol 12-hydroxystearate)

Cat. No.: HY-Y1893
COA
SDS
Instruction de manipulation Technical Support

Solutol HS-15, a Macrogol 15 hydroxy stearate, is a permeability enhancer.

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Solutol HS-15

Solutol HS-15 Chemical Structure

CAS No. : 61909-81-7

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Based on 21 publication(s) in Google Scholar

Solutol HS-15 Related Antibodies

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Description

Solutol HS-15, a Macrogol 15 hydroxy stearate, is a permeability enhancer[1].

In Vitro

Solutol HS-15 is used to increase the aqueous solubility of Biopharmaceutical Classification System (BCS) Class 2 and 4 lipophilic molecules. Solutol HS-15 has shown an enhancement in permeability of medium sized biological drugs across epithelia[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Solutol HS-15 Related Antibodies
Formule

(C2H4O)nC18H36O3
CAS No.
Appearance

Oil

Color

Colorless to off-white

SMILES

CCCCCCC(O)CCCCCCCCCCC(OCCO)=O.[n]
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

4°C, sealed storage, away from moisture
Solvant et solubilité
In Vitro: 

Ethanol : 100 mg/mL (Need ultrasonic)

H2O : 25 mg/mL (Need ultrasonic)

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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=
Concentration
×
Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Pureté et documentation

SDS (393 KB)

COA (241 KB)

Instruction de manipulation (2659 KB)
Références
Test cellulaire
[1]

For both MTS and LDH cell viability assays, cells are seeded at a density of 1×104 cells on 96-well plates and cultured for a minimum of 24 h. Solutol HS-15 (in 25 mM HBSS:HEPES, pH 7.4) solutions are applied at concentrations above and below the critical micelle concentration (CMC) (0.01 mM to 20 mM) and cytotoxicity is determined using the MTS and LDH assays. 25 mM HBSS:HEPES is used as a negative control and Triton-X 100 (3 mM) as a positive control. Following 3 h incubation, the MTS reagent in media and LDH working solution are added to the cells and the cells are incubated for a further 3 h at 37°C[1].

MCE n'a pas confirmé de manière indépendante l'exactitude de ces méthodes. Ils sont pour référence seulement.
Références
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Solutol HS-15 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Solutol HS-1561909-81-7Polyethylene glycol 12-hydroxystearateSolutol HS15Solutol HS 15Biochemical Assay ReagentsSolutolHS-15 Kolliphor HS 1570142-34-6Inhibitorinhibitorinhibit

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SAFETY DATA SHEET (SDS)

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