2. Antibody-drug Conjugate/ADC Related PROTAC
  3. ADC Linker PROTAC Linkers
  4. TCO-PEG4-NHS ester

TCO-PEG4-NHS ester 

Cat. No.: HY-141167 Purity: ≥95.0%
COA Handling Instructions

TCO-PEG4-NHS ester is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. TCO-PEG4-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

For research use only. We do not sell to patients.

TCO-PEG4-NHS ester Chemical Structure

TCO-PEG4-NHS ester Chemical Structure

CAS No. : 1613439-69-2

Size Price Stock Quantity
5 mg USD 77 In-stock
10 mg USD 120 In-stock
25 mg USD 240 In-stock
50 mg USD 380 In-stock
100 mg USD 610 In-stock
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500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of TCO-PEG4-NHS ester:

TCO-PEG4-NHS ester Related Antibodies

Top Publications Citing Use of Products

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Cleavable Non-cleavable Acid Cleavable Disulfide Cleavable Protease Cleavable Glycosidase Cleavable Phosphatase Cleavable

View All PROTAC Linkers Isoform Specific Products:

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PEGs Alkyl-Chain Alkyl/ether

  • Biological Activity

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Description

TCO-PEG4-NHS ester is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. TCO-PEG4-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

IC50 & Target[1]

Cleavable

 

PEGs

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

TCO-PEG4-NHS ester Related Antibodies
Molecular Weight

514.57

Appearance

Oil

Formula

C24H38N2O10
CAS No.
SMILES

O=C(OC1CC/C=C\CCC1)NCCOCCOCCOCCOCCC(ON2C(CCC2=O)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (97.17 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9434 mL 9.7169 mL 19.4337 mL
5 mM 0.3887 mL 1.9434 mL 3.8867 mL
10 mM 0.1943 mL 0.9717 mL 1.9434 mL
*Please refer to the solubility information to select the appropriate solvent.
Purity & Documentation

Purity: 99.58%

COA (242 KB) LCMS (188 KB)

Handling Instructions (2659 KB)
References
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TCO-PEG4-NHS ester Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

TCO-PEG4-NHS ester1613439-69-2ADC LinkerPROTAC LinkersAntibody-drug conjugates linkercleavableADCantibody-drugconjugatesInhibitorinhibitorinhibit

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