2. Metabolic Enzyme/Protease
  3. Xanthine Oxidase
  4. Xanthine oxidoreductase-IN-3

Xanthine oxidoreductase-IN-3 is an orally active xanthine oxidoreductase (XOR) inhibitor, with an IC50 of 26.3 nM. Xanthine oxidoreductase-IN-3 can be used for the research of acute hyperuricemia.

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Xanthine oxidoreductase-IN-3

Xanthine oxidoreductase-IN-3 Chemische Struktur

CAS. Nr. : 651769-78-7

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Beschreibung

Xanthine oxidoreductase-IN-3 is an orally active xanthine oxidoreductase (XOR) inhibitor, with an IC50 of 26.3 nM. Xanthine oxidoreductase-IN-3 can be used for the research of acute hyperuricemia[1].

IC50 & Target

IC50: 26.3 nM (xanthine oxidoreductase)[1]
In Vivo

Xanthine oxidoreductase-IN-3 (compound IIIa) (5 mg/kg; p.o.) shows a uric acid-lowering effect from 3 h after administration in mice with acute hyperuricemia[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: ICR mice (18-22 g) were induced acute hyperuricemia by injection of potassium oxonate and hypoxanthine[1]
Dosage: 5 mg/kg
Administration: Suspended in 0.5% CMC-Na solution for intragastric administration
Result: Showed a uric acid-lowering effect from 3 h after administration.
Molekulargewicht

299.72

Formel

C14H10ClN5O
CAS. Nr.
SMILES

O=C(C1=CC=C(C=C1)C2=NN=NN2)NC3=CC=C(C=C3)Cl
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.
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Xanthine oxidoreductase-IN-3 Related Classifications

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    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Xanthine oxidoreductase-IN-3651769-78-7Xanthine OxidaseXOxanthine oxidoreductaseXORacute hyperuricemiaInhibitorinhibitorinhibit

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