1. Immunology/Inflammation
    NF-κB
    Metabolic Enzyme/Protease
    Apoptosis
  2. Reactive Oxygen Species
    Apoptosis
  3. Xylopine

Xylopine 

Cat. No.: HY-N9534
Handling Instructions

Xylopine is an aporphine alkaloid with cytotoxic activity on cancer cells. Xylopine induces oxidative stress, causes G2/M cell cycle arrest and apoptosis in cancer cells.

For research use only. We do not sell to patients.

Xylopine Chemical Structure

Xylopine Chemical Structure

CAS No. : 517-71-5

Size Stock
100 mg   Get quote  
250 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Xylopine is an aporphine alkaloid with cytotoxic activity on cancer cells. Xylopine induces oxidative stress, causes G2/M cell cycle arrest and apoptosis in cancer cells[1].

In Vitro

Xylopine (3.5 μM-14 μM; 24-48 hours) displays potent cytotoxicity in a time- and does-depenpent manner[1].
Xylopine (72 h) has cytotoxic activity, with IC50 values ranging from 6.4 to 26.6 μM in eight different cancer cell lines (MCF7, HCT116, HepG2, SCC-9, HSC-3, HL-60, K-562, and B16-F10)[1].
Xylopine (3.5 μM-14 μM; 24-48 hours) causes cell cycle block at the phase G2/M, which is followed by internucleosomal DNA fragmentation[1].
Xylopine (3.5 μM-14 μM; 24-48 hours) significantly increases the early and late apoptosis, induces mitochondrial depolarization, and increases caspase-3 activation[1].
Xylopine also causes an increase in the production of reactive oxygen/nitrogen species (ROS/RNS), including hydrogen peroxide and nitric oxide, but not superoxide anion, and reduces glutathione levels are decreased in Xylopine-treated HCT116 cells[1]. HCT116 cells[1] 3.5 μM, 7 μM, and 14 μM 24 hours, 48 hours Induced G2/M phase arrest. HCT116 cells[1] 3.5 μM, 7 μM, and 14 μM 24 hours, 48 hours Significantly increased the early and late apoptosis.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: HCT116 cells
Concentration: 3.5 μM, 7 μM, and 14 μM
Incubation Time: 24 hours, 48 hours
Result: Displayed potent cytotoxicity in HCT116 cells.

Cell Cycle Analysis[1]

Cell Line: HCT116 cells
Concentration: 3.5 μM, 7 μM, and 14 μM
Incubation Time: 24 hours, 48 hours
Result: Induced G2/M phase arrest.

Apoptosis Analysis[1]

Cell Line: HCT116 cells
Concentration: 3.5 μM, 7 μM, and 14 μM
Incubation Time: 24 hours, 48 hours
Result: Significantly increased the early and late apoptosis.
Molecular Weight

295.33

Formula

C₁₈H₁₇NO₃

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.
  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

 

Salutation

Applicant Name *

 

Email address *

Phone number *

 

Organization name *

Department *

 

Requested quantity *

Country or Region *

     

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Xylopine
Cat. No.:
HY-N9534
Quantity:
MCE Japan Authorized Agent: