α-Amylase/α-Glucosidase-IN-4 

α-Amylase/α-Glucosidase-IN-4 (compound 5) is a dual inhibitor of α-glucosidase (Glucosidase) and α-amylase (Amylases) with IC₅₀s of 0.15 μM and 1.10 μM, respectively. α-Amylase/α-Glucosidase-IN-4 has potential antidiabetic activity^[1].

IC50: 0.15 μM (α-Glucosidase), 1.10 μM (α-Amylases)^[1]

654.58

C₃₂H₂₆N₆O₁₀

O=C(OCC)C1=C(NC2=CC=C([N+]([O-])=O)C=C2)CC(N(C3=CC=C([N+]([O-])=O)C=C3)C1C4=CC=CC([N+]([O-])=O)=C4)C5=CC([N+]([O-])=O)=CC=C5

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Saleem F, et al. Multicomponent diastereoselective synthesis of tetrahydropyridines as α-amylase and α-glucosidase enzymes inhibitors. Future Med Chem. 2023 Aug 31.. .  [Content Brief]